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Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)- manufacturers
- GLUT inhibitor-1
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- $1990.00
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2026-07-14
- CAS:2421141-40-2
- Purity: 97.35%
- Supply Ability: 10g
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| | Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)- Basic information |
| Product Name: | Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)- | | Synonyms: | Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)-;GLUT inhibitor-1;2-(3-(4-((4-(1H-Pyrazol-4-yl)phenyl)amino)-6-cyclobutyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)phenoxy)-N-(1-methylcyclopropyl)acetamide;2-[3-(6-cyclobutyl-4-{[4-(1H-pyrazol-4-yl)phenyl]amino}-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-2-yl)phenoxy]-N-(1-methylcyclopropyl)acetamide | | CAS: | 2421141-40-2 | | MF: | C32H35N7O2 | | MW: | 549.67 | | EINECS: | | | Product Categories: | | | Mol File: | 2421141-40-2.mol | ![Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)- Structure](CAS/20210305/GIF/2421141-40-2.gif) |
| | Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)- Chemical Properties |
| Boiling point | 752.1±60.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 14.10±0.50(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)- Usage And Synthesis |
| Uses | GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1]. | | Biological Activity | GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC50s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases[1].
Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1]. Parameter Mouse Rat oral Cmax (ng/mL)25251675 oral AUC (ng/mL)58906813 CL (mL/min/kg)4037 Vdss (L/Kg)1.70 4.51 t1/2 (h)0.7852.59 F (%)45.449.4 B/Pb0.05b: Solubility is determined in PBS buffer solutions. | | in vivo | Summary of the pharmacokinetic parameters of GLUT inhibitor-1 (compound 15b; 30 mg/kg) in mouse and rat[1].
| Parameter | Mouse | Rat | | oral Cmax (ng/mL) | 2525 | 1675 | | oral AUC (ng/mL) | 5890 | 6813 | | CL (mL/min/kg) | 40 | 37 | | Vdss (L/Kg) | 1.70 | 4.51 | | t1/2 (h) | 0.785 | 2.59 | | F (%) | 45.4 | 49.4 | | B/Pb | 0.05 | |
b: Solubility is determined in PBS buffer solutions.
| | IC 50 | GLUT1: 242 nM (IC50); GLUT3: 179 nM (IC50) | | References | [1]. Liu KG, et al. Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem. 2020;63(10):5201-5211. |
| | Acetamide, 2-[3-[6-cyclobutyl-5,6,7,8-tetrahydro-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]pyrido[4,3-d]pyrimidin-2-yl]phenoxy]-N-(1-methylcyclopropyl)- Preparation Products And Raw materials |
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