| Company Name: |
TargetMol |
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400-821-0310 15002144251 |
| Email: |
xuexiang.shao@tsbiochem.com |
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| | Moclobemide-d8 Basic information |
| Product Name: | Moclobemide-d8 | | Synonyms: | 4-chloro-N-[2-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)ethyl]benzamide;Moclobemide-D8 (Standard) | | CAS: | 2309010-25-9 | | MF: | C13H9ClD8N2O2 | | MW: | 276.79 | | EINECS: | | | Product Categories: | | | Mol File: | 2309010-25-9.mol |  |
| | Moclobemide-d8 Chemical Properties |
| Boiling point | 447.694±40.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.206±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| | Moclobemide-d8 Usage And Synthesis |
| Uses | Moclobemide-d8 (Ro111163-d8) is the deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Nafiz ncü Can, et al. Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity. Molecules. 2017 Aug 20;22(8):1381. DOI:10.3390/molecules22081381
[3] Yun-feng Li, et al. Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice. Acta Pharmacol Sin. 2004 Nov;25(11):1408-12. PMID:15525460 |
| | Moclobemide-d8 Preparation Products And Raw materials |
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