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1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride

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1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride manufacturers
1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride Basic information
Product Name:1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride
Synonyms:GlafenineHCl;Glafenin hydrochloride;GLAFENINE HYDROCHLORIDE;2,3-Dihydroxypropyl 2-((7-chloroquinolin-4-yl)amino)benzoate hydrochloride;inhibit,Glafenine Hydrochloride,Glafenine,Glafenin,Inhibitor;1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride
CAS:65513-72-6
MF:C19H18Cl2N2O4
MW:409.26
EINECS:
Product Categories:
Mol File:65513-72-6.mol
1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride Structure
1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride Chemical Properties
storage temp. Inert atmosphere,Room Temperature
solubility DMSO : ≥ 60 mg/mL (146.61 mM)
form Solid
color Light yellow to yellow
Major Applicationforensics and toxicology
pharmaceutical (small molecule)
InChI1S/C19H17ClN2O4.ClH/c20-12-5-6-14-17(7-8-21-18(14)9-12)22-16-4-2-1-3-15(16)19(25)26-11-13(24)10-23;/h1-9,13,23-24H,10-11H2,(H,21,22);1H
InChIKeyCEUMONXVSJOJIH-UHFFFAOYSA-N
SMILESCl.OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS CB2687000
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride Usage And Synthesis
UsesAnalgesic
in vivo

Glafenine injection (25 mg/kg i.v.) shows enhanced BLI signal in mice with an average of 2.9-fold signal enhancement over the control. Glafenine causes increases in BLI signal of up to 11.6- and 17.4-fold in two separate HEK293/ABCG2/fLuc xenografts in the same mouse compared to the signals generated by those xenografts immediately before injection[1]. Incubating polarized CFBE41o- monolayers and intestines isolated from mutant CFTR mice with glafenine increases the short-circuit current response to forskolin and genistein. Treatment with glafenine also partially restores total salivary secretion[2]. Glafenine-treated zebrafish shows evidence of endoplasmic reticulum and mitochondrial stress, with disrupted intestinal architecture and halted cell stress responses, alongside accumulation of apoptotic intestinal epithelial cells in the lumen[4].

1-Glyceryl N-[7-chloro-4-quinolyl]anthranilate hydrochloride Preparation Products And Raw materials
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