夫雷非班
| 中文名称 | 夫雷非班 |
|---|---|
| 中文同义词 | 夫雷非班;化合物 Fradafiban |
| 英文名称 | Fradafiban |
| 英文同义词 | Fradafiban;BIBU-52;3-Pyrrolidineacetic acid, 5-[[[4'-(aminoiminomethyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-2-oxo-, (3S,5S)-;Fradafiban/BIBU-52 |
| CAS号 | 148396-36-5 |
| 分子式 | C20H21N3O4 |
| 分子量 | 367.403 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 148396-36-5.mol |
| 结构式 |  |
夫雷非班 性质
| 密度 | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 4.29±0.10(Predicted) |
Fradafiban 是一种非肽血小板糖蛋白 IIb/IIIa 复合体拮抗剂，其与人血小板 GP IIb/IIIa 复合体结合，Kd 值为 148 nM。
Kd: 148 nM (human platelet GP IIb/IIIa complex)
Fradafiban is a nonpeptide mimetic of the arginine-glycine-aspartic acid recognition sequence. Fradafiban binds with high affinity and selectivity to the human platelet GP IIb/IIIa complex and potently inhibits human platelet aggregation in vitro. Fradafiban reversibly binds to the human platelet GP IIb/IIIa complex with a K d value of 148 nM.
Fradafiban has only very limited oral activity probably due to its high polarity and thus poor absorption after oral ingestion.