1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]-

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1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]- manufacturers
1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]- Basic information
Product Name:1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]-
Synonyms:1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]-;WAY-624876;Antileishmanial agent-23
CAS:745033-86-7
MF:C20H17N3O4S2
MW:427.5
EINECS:
Product Categories:
Mol File:745033-86-7.mol
1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]- Structure
1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]- Chemical Properties
Boiling point 623.9±65.0 °C(Predicted)
density 1.52±0.1 g/cm3(Predicted)
pka3.94±0.40(Predicted)
Safety Information
MSDS Information
1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]- Usage And Synthesis
UsesAntileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC50 of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei[1].
DefinitionChEBI: 2-(1,3-benzodioxol-5-yl)-5-[[2-(4-methoxyphenyl)-4,5-dihydrothiazol-5-yl]methylthio]-1,3,4-oxadiazole is a member of benzodioxoles.
References[1] Ilari A, et al. Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors. Mol Pharm. 2018 Aug 6;15(8):3069-3078. DOI:10.1021/acs.molpharmaceut.8b00185
1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]- Preparation Products And Raw materials
Tag:1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]-(745033-86-7) Related Product Information
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