Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Suppliers list

Company Name:	Chemsky（shanghai）International Co.,Ltd.
Tel:	021-50135380
Email:	shchemsky@sina.com

Company Name:	Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel:	025-66028182 17714375163
Email:	yftan@aikonchem.com

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate manufacturers

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Basic information

Product Name:	Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate
Synonyms:	N-succinimidyl 6-(3-(2-pyridyldithio)propionamido)hexanoate;N-[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]-3-(2-pyridinyldithio)propanaMide;SPDP-C6-NHS ester;Hexanoic acid, 6-[[1-oxo-3-(2-pyridinyldithio)propyl]amino]-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-dioxopyrrolidin-1-yl 6-(3-(pyridin-2-yldisulfaneyl)propanamido)hexanoate;(2,5-dioxopyrrolidin-1-yl) 6-[3-(2-pyridyldisulfanyl)propanoylamino]hexanoate;(2,5-dioxopyrrolidin-1-yl) 6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoate;SPDP-C6-NHS
CAS:	158913-22-5
MF:	C18H23N3O5S2
MW:	425.52
EINECS:
Product Categories:	MTS and Sulfhydryl Active Reagents;MTS & Sulfhydryl Active Reagents
Mol File:	158913-22-5.mol

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Chemical Properties

Melting point	82-84°C
density	1.36±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 100 mg/mL (235.01 mM)
form	Solid
pka	15.67±0.46(Predicted)
color	White
InChI	1S/C18H23N3O5S2/c22-14(10-13-27-28-15-6-3-5-12-20-15)19-11-4-1-2-7-18(25)26-21-16(23)8-9-17(21)24/h3,5-6,12H,1-2,4,7-11,13H2,(H,19,22)
InChIKey	QYEAAMBIUQLHFQ-UHFFFAOYSA-N
SMILES	O=C1CCC(N1OC(CCCCCNC(CCSSC2=CC=CC=N2)=O)=O)=O

Safety Information

MSDS Information

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Usage And Synthesis

Description	SPDP-C6-NHS ester contains a disulfide bond which is cleavable upon reduction. The NHS ester is reactive toward primary amine and sulfhydryl groups. SPDP-C6-NHS ester is commonly used for bioconjugation and reversible crosslinkings.
Chemical Properties	White Solid
Uses	A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent.
General Description	The amine-reactive portion of SPDP reagents is the N-hydroxysuccinimide (NHS) ester. Reactions are most commonly performed in phosphate, carbonate/bicarbonate, or borate buffers at pH 7-8. Other buffers can be used provided they do not contain primary amines (or thiols or disulfide reducing reagents – see discussion of the sulfhydryl reactivity). The rate of reaction and degradation by hydrolysis increases with increasing pH; for example, the half-life of the NHS ester is several hours at pH 7 and less than 10 minutes at pH 9. NHS-ester reagents like SPDP and LC-SPDP have limited aqueous solubility and must be dissolved in organic solvent before adding them to a reaction mixture. Sulfo-NHS-ester reagents like Sulfo-LC-SPDP are water-soluble and can be added directly to aqueous reaction mixtures.
reaction suitability	reagent type: cross-linking reagent

Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate Preparation Products And Raw materials

Tag:Succinimidyl 6-[3-(2-Pyridyldithio)propionamido]hexanoate(158913-22-5) Related Product Information

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