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| | 1-(2-N-Boc-Aminoethyl)piperazine Basic information |
| Product Name: | 1-(2-N-Boc-Aminoethyl)piperazine | | Synonyms: | BUTTPARK 90\06-02;ASINEX-REAG BAS 07746391;(2-PIPERAZIN-1-YL-ETHYL)-CARBAMIC ACID TERT-BUTYL ESTER;1-(2-BOC-AMINOETHYL)PIPERAZINE;1-(2-N-BOC-AMINOETHYL)PIPERAZINE;tert-Butyl 2-piperazin-1-ylethylcarbamate;Carbamic acid, N-[2-(1-piperazinyl)ethyl]-, 1,1-dimethylethyl ester;TIMTEC-BB SBB011604 | | CAS: | 140447-78-5 | | MF: | C11H23N3O2 | | MW: | 229.32 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 140447-78-5.mol |  |
| | 1-(2-N-Boc-Aminoethyl)piperazine Chemical Properties |
| Boiling point | 357.2±27.0 °C(Predicted) | | density | 1.014±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | form | solid | | pka | 12.74±0.46(Predicted) | | color | White to off-white | | InChI | InChI=1S/C11H23N3O2/c1-11(2,3)16-10(15)13-6-9-14-7-4-12-5-8-14/h12H,4-9H2,1-3H3,(H,13,15) | | InChIKey | VPOIPCJBJNWHSJ-UHFFFAOYSA-N | | SMILES | C(OC(C)(C)C)(=O)NCCN1CCNCC1 | | CAS DataBase Reference | 140447-78-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37/39 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids |
| | 1-(2-N-Boc-Aminoethyl)piperazine Usage And Synthesis |
| Uses | 1-[2-(Boc-amino)ethyl]piperazine is used in preparation of dihydropyrimidine derivatives as bifunctional degraders for treatment and prophylaxis of target protein-mediated diseases. | | Synthesis | The general procedure for the synthesis of 1-(N-Boc-aminoethyl)piperazine from 1-CBZ-4-(BOC-aminoethyl)piperazine was as follows: hydrogen was vented into a degassed solution of benzyl 4-(2-(tert-butoxycarbonylamino)ethyl)piperazine-1-carboxylate (2.60 g, 7.16 mmol) containing 10% palladium carbon (500 mg) in methanol (50 ml), the reaction lasted for 2 hours. After completion of the reaction, the mixture was filtered through Celite. The filtrate was concentrated under vacuum to give a yellow colloidal product which was identified as tert-butyl 2-(1-piperazinyl)ethylcarbamate (1.60 g, 97% yield). | | References | [1] Patent: EP1449844, 2004, A1. Location in patent: Page 34
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 18, p. 5147 - 5157 |
| | 1-(2-N-Boc-Aminoethyl)piperazine Preparation Products And Raw materials |
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