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| | 5-Trans fluprostenol Basic information |
| Product Name: | 5-Trans fluprostenol | | Synonyms: | 9ALPHA,11ALPHA,15R-TRIHYDROXY-16-(3-(TRIFLUOROMETHYL)PHENOXY)-17-18,19,20-TETRANOR-PROSTA-5E,13E-DIEN-1-OIC ACID;WWSWYXNVCBLWNZ-BDFMIYKPSA-N;Travoprost Impurity 1（5- trans Fluprostenol）;5-Heptenoic acid, 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-, [1R-[1α(E),2β(1E,3R*),3α,5α]]- (9CI);5-Trans fluprostenol | | CAS: | 57968-83-9 | | MF: | C23H29F3O6 | | MW: | 458.47 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 5-Trans fluprostenol Chemical Properties |
| Boiling point | 607.972±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.336±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 15 mg/ml | | pka | 4.762±0.10(predicted) |
| | 5-Trans fluprostenol Usage And Synthesis |
| Description | Travoprost is the Alcon trade name for fluprostenol isopropyl ester, an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1 Fluprostenol isopropyl ester is a prodrug which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid, fluprostenol.2 5-trans Fluprostenol is an impurity that is routinely found in bulk preparations of fluprostenol in amounts ranging from 1-3%. This impurity occurs in the finished prodrug Travoprost in similar amounts. The pharmacology of 5-trans fluprostenol has not been studied extensively to date. | | Uses | 5-trans-Fluprostenol is a synthetic prostaglandin analogue[1]. | | References | 1. Hellberg, M.R., Sallee, V.L., McLaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist J. Ocul. Pharmacol. Ther. 17(5),421-432(2001).
2. Sorbera, L.A., and Castaer, J. Travoprost Drugs Future 25(1),41-45(2000). |
| | 5-Trans fluprostenol Preparation Products And Raw materials |
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