1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-

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1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Basic information
Product Name:1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
Synonyms:1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-
CAS:273727-89-2
MF:C23H25NO
MW:331.45
EINECS:
Product Categories:
Mol File:273727-89-2.mol
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Structure
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Chemical Properties
Boiling point 478.8±28.0 °C(Predicted)
density 1.083±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka7.99±0.50(Predicted)
Safety Information
MSDS Information
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Usage And Synthesis
UsesZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.
DefinitionChEBI: 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone is a member of naphthalenes.
IC 50JAK3: 7.1 (pIC50); JAK1: 4.4 (pIC50); EGF-R: 5.6 (pIC50); Lck: 5.0 (pIC50); CDK4: 5.0 (pIC50); TGM2: 10 nM (IC50)
References[1] Brown GR, et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. DOI:10.1016/s0960-894x(00)00051-2
[2] Lai TS, et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. DOI:10.1016/j.chembiol.2008.07.015
[3] Zhang Z, et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197. DOI:10.3892/ol.2017.5861
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- Preparation Products And Raw materials
Tag:1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-(273727-89-2) Related Product Information
ZM 39923 hydrochloride Naftifine Impurity 8 ZM 39923 HCl 1-Propanone, 3-[methyl(phenylmethyl)amino]-1-phenyl- 3-[Methyl(1-naphthalenylmethyl)amino]-1-phenyl-1-Propanone 1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-