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| | (5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid Basic information |
| Product Name: | (5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid | | Synonyms: | (5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid;NLUNAYAEIJYXRB-HEJOTXCHSA-N;5,9,11,14-Eicosatetraenoic acid, 8-hydroxy-, (5Z,9E,11Z,14Z)- | | CAS: | 70968-93-3 | | MF: | C20H32O3 | | MW: | 320.47 | | EINECS: | | | Product Categories: | | | Mol File: | 70968-93-3.mol |  |
| | (5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid Chemical Properties |
| Boiling point | 471.1±45.0 °C(Predicted) | | density | 0.984±0.06 g/cm3(Predicted) | | solubility | 0.1 M Na2CO3: 2 mg/ml
DMF: Miscible
DMSO: Miscible
Ethanol: MisciblePBS pH 7.2: 0.8 mg/ml | | pka | 4.75±0.10(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | (5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid Usage And Synthesis |
| Uses | (±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE). | | Definition | ChEBI: 8-HETE is an HETE having a 8-hydroxy group and (5Z)-, (9E)-, (11Z)- and (14Z)-double bonds. It has a role as a mouse metabolite. It is a conjugate acid of an 8-HETE(1-). | | References | [1] ZONGYUAN WU, FANG WEI* Analytical Strategy for Oxylipin Annotation by Combining Chemical Derivatization-Based Retention Index Algorithm and Feature Tandem Mass Spectrometric Fragmentation as a Biomarker Discovery Tool[J]. Analytical Chemistry, 2023, 95 43: 15933-15942. DOI: 10.1021/acs.analchem.3c02789
[2] DONG CHENG. MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.[J]. Cell metabolism, 2022, 34 11: 1732-1748.e5. DOI: 10.1016/j.cmet.2022.10.007
[3] YILIN PANG . LC−MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products[J]. Free Radical Biology and Medicine, 2022, 193: Pages 363-372. DOI: 10.1016/j.freeradbiomed.2022.10.303
[4] ANNE-SOPHIE ARCHAMBAULT. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients[J]. FASEB Journal, 2021, 35 6. DOI: 10.1096/fj.202100540r
[5] CARLOS ARTÉRIO SORGI. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays[J]. Scientific Data, 2018, 5 1: 1-12. DOI: 10.1038/sdata.2018.167
[6] RYOHEI AOYAGI. Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library.[J]. Journal of Lipid Research, 2017, 58 11: 2229-2237. DOI: 10.1194/jlr.d077123
[7] ALWENA H MORGAN. Quantitative assays for esterified oxylipins generated by immune cells[J]. Nature Protocols, 2010, 5 12: 1919-1931. DOI: 10.1038/nprot.2010.162 |
| | (5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid Preparation Products And Raw materials |
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