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| | 1,2,4-Triazine Basic information |
| | 1,2,4-Triazine Chemical Properties |
| Boiling point | 197℃ | | density | 1.173 | | refractive index | 1.5060 (estimate) | | Fp | 92℃ | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated, Sonicated) | | form | Gel | | pka | 0.98±0.63(Predicted) | | color | Very Dark Orange to Very Dark Brown |
| | 1,2,4-Triazine Usage And Synthesis |
| Description | 1,2,4-Triazine is an electron-deficient heteroaromatic azadiene capable of participation in inverse electron demand Diels-Alder reactions with electron-rich dienophiles. | | Uses | 1,2,4-Triazine (>90%) is used in improvements of pesticide formulations with lactamides. 1,2,4-triazines scaffold-valuable lead molecules possess diverse pharmacological activities, easy synthetic routes for synthesis and attracted researchers for development of new chemotherapeutic agents in human and mouse model. | | Definition | ChEBI: 1,2,4-triazine is a triazine and a member of 1,2,4-triazines. | | Synthesis | 1,2,4-Triazine is prepared by a cooled (-75 °C) solution of monomeric Glyoxal (90.0 mmol) in absolute MeOH (200 mL) is added to a solution of formamidrazone hydrochloride (40 mmol) in absolute MeOH (300 mL) at -50 °C. Et3N (200 mmol) is added and the resulting reaction mixture is allowed to stand at 25 °C for 24 h. The MeOH is removed in vacuo at 20 °C and the residue extracted with Et2O (peroxide free, 5×). Vacuum distillation of the residue after evaporation of the Et2O affords 1,2,4-triazine (bp 25-28 °C/0.5 mmHg). | | storage | Best stored at 0 °C or below. It is stable to acid, less stable to base, and is hygroscopic;
should be stored under anhydrous conditions since it reacts slowly with water and protic solvents. |
| | 1,2,4-Triazine Preparation Products And Raw materials |
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