Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](2-ethynyl-4-thiazolyl)- manufacturers
- BCP-T.A
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- $125.00
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2026-04-27
- CAS:2786829-70-5
- Purity: 99.94%
- Supply Ability: 10g
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| | Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](2-ethynyl-4-thiazolyl)- Basic information |
| | Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](2-ethynyl-4-thiazolyl)- Chemical Properties |
| Boiling point | 603.5±65.0 °C(Predicted) | | density | 1.42±0.1 g/cm3(Predicted) | | solubility | DMF: 3 mg/ml; DMSO: 10 mg/ml; Ethanol: 12 mg/ml | | form | A solid | | pka | 4.89±0.10(Predicted) | | color | White to light yellow |
| | Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](2-ethynyl-4-thiazolyl)- Usage And Synthesis |
| Description | BCP-T.A. is a ferroptosis inducer.1 It induces ferroptosis in NCI H522 non-small cell lung cancer (NSCLC) cells (IC50 = 17 nM), an effect that can be blocked by the ferroptosis inhibitor liproxstatin-1 . BCP-T.A. binds to glutathione peroxidase (GPX4) and increases the accumulation of lipid peroxides in NCI H522 cells when used at a concentration of 0.5 μM. It is cytotoxic to WI38 human lung fibroblasts and mouse embryonic fibroblasts (MEFs; IC50s = 22 and 10 nM, respectively), as well as NCI H522, HT-1080 fibrosarcoma, MDA-MB-468 and MDA-MB-231 breast, and HeLa cervical cancer cells (IC50s = 17, 19, 84, 21, and 242 nM, respectively). | | Uses | BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4[1]. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | 1. Karaj, E., Sindi, S.H., Kuganesan, N., et al. Tunable cysteine-targeting electrophilic heteroaromatic warheads induce ferroptosis J. Med. Chem. 65(17),11788-11817(2022). |
| | Methanone, [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](2-ethynyl-4-thiazolyl)- Preparation Products And Raw materials |
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