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| | 1H-Benzimidazole-2-carboxylicacid,1-methyl-,methylester(9CI) Basic information |
| | 1H-Benzimidazole-2-carboxylicacid,1-methyl-,methylester(9CI) Chemical Properties |
| Melting point | 88 °C | | Boiling point | 326.4±25.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 3.51±0.10(Predicted) | | Appearance | Light yellow to yellow Solid |
| | 1H-Benzimidazole-2-carboxylicacid,1-methyl-,methylester(9CI) Usage And Synthesis |
| Synthesis | To a solution of 1H-benzimidazole-2-carboxylic acid methyl ester (177 mg, 1.0 mmol) in anhydrous N,N-dimethylformamide (DMF, 5 mL) was added sodium hydride (60% dispersed in mineral oil, 62 mg, 1.5 mmol) at 0 °C under nitrogen protection. The reaction mixture was stirred at 0 °C for 0.5 h. After that, iodomethane (284 mg, 2.0 mmol) was slowly added. Subsequently, the reaction mixture was continued to be stirred at room temperature for 4 hours. After completion of the reaction, the mixture was diluted with saturated saline at 0 °C and extracted with ethyl acetate (3 x 20 mL). The combined organic phases were washed sequentially with water (2 x 15 mL) and saturated saline (20 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and purified by fast column chromatography to afford methyl 1-methyl-1H-benzimidazole-2-carboxylate (180 mg, 90% yield) as a light yellow solid.ESI-MS (M + 1): 191 (calculated value: C10H10N2O2). | | References | [1] Patent: WO2011/143365, 2011, A1. Location in patent: Page/Page column 170-171 |
| | 1H-Benzimidazole-2-carboxylicacid,1-methyl-,methylester(9CI) Preparation Products And Raw materials |
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