| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
|
| Product Name: | PBOX-6 | | Synonyms: | PBOX-6;Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7-yl ester;PBOX-6 >=98% (HPLC);6-(Naphthalen-1-yl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7-yl dimethylcarbamate;PBOX 6, 10 mM in DMSO;6- (Naphthalen-1-yl) benzo [b] pyrrolo [1,2-d] [1,4] oxazepan-7-yldimethylaminoformate ester | | CAS: | 290814-68-5 | | MF: | C25H20N2O3 | | MW: | 396.44 | | EINECS: | | | Product Categories: | | | Mol File: | 290814-68-5.mol |  |
| | PBOX-6 Chemical Properties |
| Melting point | 177-179 °C(Solv: ethanol (64-17-5)) | | Boiling point | 580.6±50.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO | | form | powder | | pka | -1.32±0.70(Predicted) | | color | white to beige |
| | PBOX-6 Usage And Synthesis |
| Uses | PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent. | | References | [1] Zisterer DM, et al. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J Pharmacol Exp Ther. 2000 Apr;293(1):48-59. PMID:10734152
[2] Mc Gee MM, et al. Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6. FEBS Lett. 2002 Mar 27;515(1-3):66-70. DOI:10.1016/s0014-5793(02)02440-7
[3] Bane FT, et al. The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells. J Pharmacol Exp Ther. 2009 Apr;329(1):38-47. DOI:10.1124/jpet.108.148130 |
| | PBOX-6 Preparation Products And Raw materials |
|