| Company Name: |
InvivoChem |
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
|
| | BMS-1233 Basic information |
| Product Name: | BMS-1233 | | Synonyms: | BMS-1233;2-Piperidinecarboxylic acid, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[(2-methyl[1,1′-biphenyl]-3-yl)methoxy]phenyl]methyl]- | | CAS: | 2447065-99-6 | | MF: | C35H33ClN2O4 | | MW: | 581.1 | | EINECS: | | | Product Categories: | | | Mol File: | 2447065-99-6.mol |  |
| | BMS-1233 Chemical Properties |
| Boiling point | 738.012±60.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.311±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 2.330±0.20(predicted) |
| | BMS-1233 Usage And Synthesis |
| Uses | BMS-1233 is an orally active inhibitor for programmed cell death-ligand 1 (PD-L1), with IC50 of 14.5 nM. BMS-1233 promotes cell death of HepG2 in a Jurkat T cell and HepG2 cell co-culture model, exhibits antitumor activity against melanoma in mouse model[1]. | | References | [1] Cheng B, et al., Bifunctional small molecules targeting PD-L1/CXCL12 as dual immunotherapy for cancer treatment. Signal Transduct Target Ther. 2023 Mar 1;8(1):91. DOI:10.1038/s41392-022-01292-5 |
| | BMS-1233 Preparation Products And Raw materials |
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