- Deltonin
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- $912.00
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2026-07-27
- CAS:55659-75-1
- Purity: 98.24%
- Supply Ability: 10g
- Deltonin
-
-
2023-02-24
- CAS:55659-75-1
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- deltonin
-
- $3.00
-
2020-01-19
- CAS:55659-75-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg,5kg,50kg
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| | deltonin Basic information |
| Product Name: | deltonin | | Synonyms: | deltonin;3-O-beta-D-Glucopyranosyl(1-4)-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside-diosgenin;Deltonin,3-O-β-D-Glucopyranosyl-(1→4)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside-diosgenin;β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-;Deltonin,Akt,Protein kinase B,PKB,Inhibitor,Extracellular signal regulated kinases,inhibit,ERK,Endogenous Metabolite;Deltonin, 10 mM in DMSO | | CAS: | 55659-75-1 | | MF: | C45H72O17 | | MW: | 885.04 | | EINECS: | | | Product Categories: | | | Mol File: | 55659-75-1.mol |  |
| | deltonin Chemical Properties |
| Melting point | 298-300 °C (decomp) | | density | 1.42±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | form | Solid | | pka | 12+-.0.70(Predicted) | | color | White to off-white |
| | deltonin Usage And Synthesis |
| Uses | Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, has antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. | | Definition | ChEBI: Deltonin is a triterpenoid. | | in vivo | Deltonin (20 and 40 mg/kg, p.o.) reduces the tumor growth of 37.7% and 56.7%, and causes a 50-day survival rate of 60% and 50%, respectively, in mice. Deltonin also inhibits tumor angiogenesis in mice[1]. | | IC 50 | ERK1; ERK2; Akt | | References | [1] Tong QY, et al. Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cell Physiol Biochem. 2011;27(3-4):233-42. DOI:10.1159/000327949
[2] Zhang S, et al. Deltonin induces apoptosis in MDAMB231 human breast cancer cells via reactive oxygen speciesmediated mitochondrial dysfunction and ERK/AKT signaling pathways. Mol Med Rep. 2013 Mar;7(3):1038-44. DOI:10.3892/mmr.2013.1273 |
| | deltonin Preparation Products And Raw materials |
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