|
|
| | JAB-2485 Basic information |
| Product Name: | JAB-2485 | | Synonyms: | JAB-2485;4-Piperidinecarboxylic acid, 1-[(3-chloro-2-fluorophenyl)methyl]-4-[[5-fluoro-4-methyl-6-[(3-methyl-1H-pyrazol-5-yl)amino]-2-pyridinyl]methyl]-2-methyl-, (2R,4R)- | | CAS: | 2899209-55-1 | | MF: | C25H28ClF2N5O2 | | MW: | 503.97 | | EINECS: | | | Product Categories: | | | Mol File: | 2899209-55-1.mol |  |
| | JAB-2485 Chemical Properties |
| Boiling point | 627.0±55.0 °C(predicted) | | density | 1.367±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 2.97±0.40(predicted) | | form | Solid | | color | White to off-white (Solid) |
| | JAB-2485 Usage And Synthesis |
| Uses | JAB-2485 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0.33 nM. JAB-2485 exhibits around 1700-fold selectivity for AURKA over AURKB. JAB-2485 induces cell cycle arrest and apoptosis. JAB-2485 can be used for the research of cancer[1]. | | References | [1] Yang G, et, al. Abstract 1645: JAB-2485: A potent, highly selective small-molecule Aurora kinase A inhibitor that targets cell division. Cancer Res (2023) 83 (7_Supplement): 1645. |
| | JAB-2485 Preparation Products And Raw materials |
|