萘法唑酮盐酸盐
| 中文名称 | 萘法唑酮盐酸盐 |
|---|---|
| 中文同义词 | 萘法唑酮盐酸盐;盐酸奈法唑酮;盐酸萘法唑酮;盐酸奈法唑酮 标准品;萘法唑酮盐酸盐 USP标准品;DUTONIN|||MJ-13754-1|||SERZONE|||BMY-13754-1|||BMY-13754|||萘法唑酮盐酸盐;1-(3-(4-(3-氯苯基)哌嗪-1-基)丙基)-3-乙基-4-(2-苯氧基乙基)-1H-1,2,4-三唑-5(4H)-酮盐酸盐;乙腈中奈法唑酮盐酸盐(以奈法唑酮计) |
| 英文名称 | Nefazodone hydrochloride |
| 英文同义词 | NEFAZODONE-D5 HCL;3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride;Nefazodone HCl;Nefazodone hydrochloride;NEFAZODONE;BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride;Nefazodone Hydrochloride (200 mg) |
| CAS号 | 82752-99-6 |
| 分子式 | C25H33Cl2N5O2 |
| 分子量 | 506.47 |
| EINECS号 | |
| 相关类别 | 医药原料药;哌嗪;SERZONE;Active Pharmaceutical Ingredients;Serotonin receptor;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API |
| Mol文件 | 82752-99-6.mol |
| 结构式 |  |
萘法唑酮盐酸盐 性质
| 熔点 | 186-188°C |
|---|---|
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMSO: 11 mg/mL at 60 °C |
| 形态 | 固体 |
| 颜色 | 白色 |
| 最大波长(λmax) | 248nm(MeOH)(lit.) |
| Merck | 14,6438 |
| InChI | 1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H |
| InChIKey | DYCKFEBIOUQECE-UHFFFAOYSA-N |
| SMILES | O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl |
| CAS 数据库 | 82752-99-6(CAS DataBase Reference) |
|
5-HT 2A Receptor 5.8 nM (Ki) |
α1-adrenergic receptor
|
Nefazodone hydrochloride (BMY-13754) is a phenylpiperazine antidepressant with a mechanism of action that is distinct from those of other currently available drugs. Nefazodone hydrochloride potently and selectively blocks postsynaptic serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptors and moderately inhibits serotonin and noradrenaline (norepinephrine) reuptake. Nefazodone hydrochloride is also an inhibitor of the hepatic P-450 isoenzyme CYP3A4.
95885-13-5
52605-52-4
82752-99-6
实施例6：将5-乙基-4-(2-苯氧基乙基)-2H-1,2,4-三唑-3(4H)-酮（60.0 g，0.257 mol）、1-(3-氯苯基)-4-(3-氯丙基)哌嗪盐酸盐（79.7 g，0.257 mol）、氢氧化钠（26.7 g，0.669 mol）和400 mL异丙醇混合，搅拌并加热回流10至18小时。反应完成后，用37%盐酸（35 mL，0.42 mol）酸化反应混合物，随后减压浓缩去除溶剂。将残余物与400 mL二氯甲烷搅拌，过滤后减压浓缩滤液。残余物从600 mL异丙醇中结晶，得到81.5 g（62.5%收率）的2-[3-[4-(3-氯苯基)-1-哌嗪基]丙基]-5-乙基-2,4-二氢-4-(2-苯氧基乙基)-3H-1,2,4-三唑-3-酮盐酸盐。产物进一步从水和异丙醇中结晶，得到纯品，熔点为180°C-182.5°C。产物的光谱数据（NMR、13C NMR、IR）和元素分析结果与实施例2中获得的相同产物数据一致。
参考文献：
[1] Patent: US4487773, 1984, A
安全信息
| 安全说明 | 22-24/25 |
|---|---|
| 危险品运输编号 | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS号 | XZ5483009 |
| 海关编码 | 2933595960 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S5398 | 萘法唑酮盐酸盐 Nefazodone hydrochloride | 82752-99-6 | 10mg | 794.97元 |
| 2026/06/05 | HY-B1396R | 萘法唑酮盐酸盐 Nefazodone hydrochloride (Standard) | 82752-99-6 | 5 mg | 1100元 |