|
|
| | Ethyl 6-bromo-1H-indazole-3-carboxylate Basic information |
| Product Name: | Ethyl 6-bromo-1H-indazole-3-carboxylate | | Synonyms: | KY003015;6-BroMo-1H-indazole-3-carboxyile acid ethyl ester;1H-Indazole-3-carboxylic acid, 6-broMo-, ethyl ester;6-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl 6-Bromoindazole-3-carboxylate;Ethyl 6-bromo-1H-indazole-3-carboxylate | | CAS: | 885272-94-6 | | MF: | C10H9BrN2O2 | | MW: | 269.09 | | EINECS: | | | Product Categories: | | | Mol File: | 885272-94-6.mol |  |
| | Ethyl 6-bromo-1H-indazole-3-carboxylate Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Appearance | White to off-white Solid |
| | Ethyl 6-bromo-1H-indazole-3-carboxylate Usage And Synthesis |
| Synthesis | To a solution of 6-bromoindazole-3-carboxylic acid (4.4 g, 18.25 mmol) in ethanol (100 mL) was slowly added thionyl chloride (666 mL, 91 mmol), followed by heating and refluxing the reaction mixture for 3 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and purified by fast column chromatography to afford ethyl 6-bromo-1H-indazole-3-carboxylate (2.1 g, 39% yield) as a tan solid. Mass spectrum (ESI) m/z: 270.9 (M + H). NMR hydrogen spectrum (400MHz, CDCl3) δ 8.08 (d, J = 8.6Hz, 1H), 7.95 (s, 1H), 7.44 (d, J = 8.6Hz, 1H), 4.57 (q, J = 7.0Hz, 2H), 1.51 (t, J = 7.2Hz, 3H). | | References | [1] Patent: WO2017/123860, 2017, A1. Location in patent: Page/Page column 248 |
| | Ethyl 6-bromo-1H-indazole-3-carboxylate Preparation Products And Raw materials |
|