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| | 6-HYDROXY-3-PYRIDINEBORONIC ACID Basic information |
| Product Name: | 6-HYDROXY-3-PYRIDINEBORONIC ACID | | Synonyms: | 6-HYDROXY-3-PYRIDINEBORONIC ACID;5-BORONO-2-PYRIDONE;1,6-Dihydro-6-oxopyridine-3-boronic acid;2-Hydroxypyridine-5-boronic acid;B-(1,6-dihydro-6-oxo-3-pyridinyl)-Boronic acid;(6-oxo-1,6-dihydropyridin-3-yl)boronic acid;(6-oxo-1H-pyridin-3-yl)boronic acid;(6-oxo-5,6-dihydropyridin-3-yl)boronic acid | | CAS: | 903899-13-8 | | MF: | C5H6BNO3 | | MW: | 138.92 | | EINECS: | | | Product Categories: | | | Mol File: | 903899-13-8.mol |  |
| | 6-HYDROXY-3-PYRIDINEBORONIC ACID Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml,Ethanol: 1 mg/ml | | pka | 8.02±0.20(Predicted) | | form | A crystalline solid | | color | White to off-white | | InChI | InChI=1S/C5H6BNO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3,9-10H,(H,7,8) | | InChIKey | YUOLAYZNDYRBEZ-UHFFFAOYSA-N | | SMILES | B(C1C=CC(=O)NC=1)(O)O |
| RIDADR | 2811 | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 2933399990 |
| | 6-HYDROXY-3-PYRIDINEBORONIC ACID Usage And Synthesis |
| Uses | 6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors[1][2]. | | References | [1] Hendricks RT, et al. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. DOI:10.1016/j.bmcl.2008.11.060
[2] Verheijen JC, et al. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. DOI:10.1021/jm9013828 |
| | 6-HYDROXY-3-PYRIDINEBORONIC ACID Preparation Products And Raw materials |
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