PPARδ agonist 11

Request For Quotation
PPARδ agonist 11 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
PPARδ agonist 11 Basic information
Product Name:PPARδ agonist 11
Synonyms:PPARδ agonist 11;Acetic acid, 2-[2-methyl-4-[[[5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl]methyl]thio]phenoxy]-
CAS:2982696-04-6
MF:C19H15F3N2O3S2
MW:440.46
EINECS:
Product Categories:
Mol File:2982696-04-6.mol
PPARδ agonist 11 Structure
PPARδ agonist 11 Chemical Properties
Boiling point 570.9±60.0 °C(predicted)
density 1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka3.16±0.10(predicted)
Safety Information
MSDS Information
PPARδ agonist 11 Usage And Synthesis
UsesPPARδ agonist 11 (Compound 11) is a selective agonist for PPARδ with an EC50 of 20 nM. PPARδ agonist 11 reduces the levels of nitrite oxide (NO), proinflammatory cytokines TNFα and IL-6 in LPS (HY-D1056)-stimulated RAW264.7 cell, and exhibits anti-inflammatory efficacy via NF-κB pathway. PPARδ agonist 11 exhibits good stability in human liver microsomes and plasma. PPARδ agonist 11 ameliorates Carrageenan (HY-125474)-induced foot edema[1].
IC 50hPPARδ: 0.02 μM (EC50); hPPARα: 8 μM (EC50)
References[1] Kim J, et al., Discovery of the therapeutic potential of PPARδ agonist bearing 1,3,4- thiadiazole in inflammatory disorders. Eur J Med Chem. 2024 Sep 12;279:116856. DOI:10.1016/j.ejmech.2024.116856
PPARδ agonist 11 Preparation Products And Raw materials
Tag:PPARδ agonist 11(2982696-04-6) Related Product Information
PPARδ agonist 11 Acetic acid, 2-[2-methyl-4-[[[5-[4-(trifluoromethoxy)phenyl]-1,3,4-thiadiazol-2-yl]methyl]thio]phenoxy]- CD40 Protein, HUMAN (HEK293, FC) TRAIL R1/TNFRSF10A protein, HUMAN (BIOTINYLATED, HEK293, HIS-AVI) TRAIL R2/TNFRSF10B Protein, HUMAN (127A.A, HEK293, HIS) CD40 Protein, Human (HEK293, His)