| Company Name: |
Tcichem, Inc. |
| Tel: |
13918644899 |
| Email: |
81587635@qq.com |
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| | N-METHYLPIPERIDINE-4-CARBOXAMIDE Basic information |
| Product Name: | N-METHYLPIPERIDINE-4-CARBOXAMIDE | | Synonyms: | N-Methyl-4-piperidinecarboxaMide;4-Piperidinecarboxamide, N-methyl-;N-methylpiperidin-4-carboxylic acid amide;N-Methyl-piperidin-4-carboxamide;N-METHYLPIPERIDINE-4-CARBOXAMID | | CAS: | 1903-69-1 | | MF: | C7H14N2O | | MW: | 142.2 | | EINECS: | | | Product Categories: | | | Mol File: | 1903-69-1.mol |  |
| | N-METHYLPIPERIDINE-4-CARBOXAMIDE Chemical Properties |
| Melting point | 123~125℃ | | Boiling point | 318.5±31.0 °C(Predicted) | | density | 0.997±0.06 g/cm3(Predicted) | | pka | 16.06±0.20(Predicted) | | form | powder | | color | Yellow |
| HazardClass | IRRITANT | | HS Code | 2933399990 |
| | N-METHYLPIPERIDINE-4-CARBOXAMIDE Usage And Synthesis |
| Synthesis | GENERAL STEPS: 1-Boc-4-piperidinyl-N-methylamide (68 mg, 0.28 mmol) was dissolved in methanol (2 mL) and cooled to 0°C. A 1,4-dioxane solution (2 mL) of 4 M hydrogen chloride was slowly added. The reaction mixture was stirred at 0°C for 15 minutes and then gradually warmed to room temperature and continued stirring for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by SCX-2 column chromatography, eluting first with methanol and then with 0.5 M ammonia in methanol solution to afford N-methylpiperidine-4-carboxamide as a colorless oil (41 mg, 99% yield). The product was detected by infrared spectroscopy (CHCl3) with characteristic absorption peaks of 1308, 2948, 1663, 1525, 1227, 1119 cm-1; mass spectrometry (ESI) analysis showed that the theoretical value of the [M+H]+ ion peak of C7H15N2O was 143.1179 and the measured value was 143.1178. | | References | [1] Patent: WO2010/41054, 2010, A1. Location in patent: Page/Page column 32 |
| | N-METHYLPIPERIDINE-4-CARBOXAMIDE Preparation Products And Raw materials |
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