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| | 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane
Basic information |
| Product Name: | 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane
| | Synonyms: | 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane;3,8-Diazabicyclo[3.2.1]octane, 8-(phenylmethyl)-;8-Benzyl-3,8-diazabicyclo[3.2.1]octane - [B13366];rel-(1R,5S)-8-benzyl-3,8-diazabicyclo[3.2.1]octane | | CAS: | 93428-56-9 | | MF: | C13H18N2 | | MW: | 202.3 | | EINECS: | | | Product Categories: | | | Mol File: | 93428-56-9.mol | ![8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane
Structure](CAS/GIF/93428-56-9.gif) |
| | 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane
Chemical Properties |
| Boiling point | 309℃ | | density | 1.074 | | Fp | 131℃ | | storage temp. | Store at 0-8 °C | | pka | 9.77±0.20(Predicted) | | Appearance | white solid |
| | 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane
Usage And Synthesis |
| Synthesis | Cignarella et al. first reported the synthesis of 3,8-diazabicyclo[3.2.1]octane derivatives. Several 3-substituted-8-methyl-3,8-diazabicyclo[3.2.1]octanes were synthesized starting from 2,5-dicarbethoxypyrrolidine, which was converted into N-carbobenzoxy-2,5-pyrrolidine dicarboxylic acid anhydride in three steps. The latter reacted with appropriate amines to give 3-substituted-8-carbobenzoxy-3,8-diazabicyclo[3.2.1]octanes-2,4-diones from which the corresponding bicyclic bases were obtained by reduction with lithium aluminium hydride. The process suffers from several disadvantages such as long steps, tedious and labrious isolation of intermediates and low overall yields. A more efficient synthesis of 3-benzyl-3,8-diazabicyclo[3.2.1]octanes was subsequently reported soon and has being used today (as below).
![8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane](/NewsImg/2025-12-10/6390097659283176706447225.png "8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane") |
| | 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane
Preparation Products And Raw materials |
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