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| | 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL Basic information |
| Product Name: | 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL | | Synonyms: | 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL;MFCD11043099;Lercanidipine Related Compound 2;2-Propanol, 2-methyl-1-(methylamino)-;2-?Methyl-?1-?(methylamino)?-?2-?propanol | | CAS: | 67622-86-0 | | MF: | C5H13NO | | MW: | 103.16 | | EINECS: | | | Product Categories: | | | Mol File: | 67622-86-0.mol |  |
| | 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL Chemical Properties |
| Boiling point | 142-143 °C | | density | 0.8875 g/cm3(Temp: 23 °C) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 14.97±0.29(Predicted) | | Appearance | Colorless to light yellow Liquid |
| RIDADR | UN2735 | | HazardClass | 8 |
| | 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL Usage And Synthesis |
| Uses | 2-Methyl-1-(methylamino)-2-propanol is a general reagent used in the synthesis of thiophene-anthranilamides which act as potent and orally active factor Xa inihibitors. | | Synthesis | 2-Methyl-1-(methylamino)propan-2-ol was prepared as follows: 1-chloro-2-methyl-2-propanol (103L, 1.00 mmol) was dissolved in 40% methylamine methanol solution (0.5 mL) and stirred in a microwave chemical synthesis unit (CEMDiscover) for 15 min at 100C at 100W. After cooling to room temperature, the solvent was removed by distillation under reduced pressure, acetonitrile (3 mL) was added and the precipitated solid was filtered off. After adding aqueous sodium bicarbonate (10 drops) to the filtrate, the solvent was removed by distillation under reduced pressure to give a crude concentrate of 2-methyl-1-(methylamino)propan-2-ol. |
| | 2-METHYL-1-(METHYLAMINO)PROPAN-2-OL Preparation Products And Raw materials |
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