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| | Exendin-4 (5-39) amide (trifluoroacetate salt) Basic information |
| | Exendin-4 (5-39) amide (trifluoroacetate salt) Chemical Properties |
| solubility | Water: soluble |
| | Exendin-4 (5-39) amide (trifluoroacetate salt) Usage And Synthesis |
| Description | Exendin-4 (5-39) amide is a 34-amino acid synthetic peptide corresponding to residues 5-39 of exendin-4 (48-86) amide (Item No. 11096) and an antagonist of the glucagon-like peptide 1 (GLP-1) receptor (IC50 = 0.3 nM) that has roles in synaptic transmission.1 It decreases GLP-1-induced increases in intracellular cAMP levels in CHO/pancGLPR cells. Exendin-4 (5-39) amide (10 and 100 nM) increases extracellular glutamate reuptake in primary rat hippocampal astrocytes.2 In vivo, exendin-4 (5-39) amide increases excitatory amino acid transporter 2 (EAAT2) protein levels and decreases the field excitatory postsynaptic potential decay time in the rat dentate gyrus when administered intracerebroventricularly.WARNING This product is not for human or veterinary use. | | References | [1] C MONTROSE-RAFIZADEH. High potency antagonists of the pancreatic glucagon-like peptide-1 receptor.[J]. The Journal of Biological Chemistry, 1997, 272 34: 21201-21206. DOI: 10.1074/jbc.272.34.21201
[2] KAZUMA KOBAYASHI. Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus[J]. Brain Research, 2013, 1505: Pages 1-10. DOI: 10.1016/j.brainres.2013.01.012 |
| | Exendin-4 (5-39) amide (trifluoroacetate salt) Preparation Products And Raw materials |
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