|
|
| | Exendin-3 (9-39) amide (trifluoroacetate salt) Basic information |
| | Exendin-3 (9-39) amide (trifluoroacetate salt) Chemical Properties |
| solubility | DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 0.5 mg/mlPBS (pH 7.2): 10 mg/ml |
| | Exendin-3 (9-39) amide (trifluoroacetate salt) Usage And Synthesis |
| Description | Exendin-3 (9-39) amide is a truncated form of the exendin-4 (48-86) amide (Item No. 11096) peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1).1 It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM).2 Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 µg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats.3WARNING This product is not for human or veterinary use. | | References | [1] B THORENS. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor.[J]. Diabetes, 1993, 42 11: 1678-1682. DOI: 10.2337/diab.42.11.1678
[2] J P RAUFMAN J E L Singh. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist.[J]. The Journal of Biological Chemistry, 1991, 266 5: 2897-2902.
[3] M. D. TURTON. A role for glucagon-like peptide-1 in the central regulation of feeding[J]. Nature, 1996, 379 6560: 69-72. DOI: 10.1038/379069a0 |
| | Exendin-3 (9-39) amide (trifluoroacetate salt) Preparation Products And Raw materials |
|