丙二腈
| 中文名称 | 丙二腈 |
|---|---|
| 中文同义词 | 1,5-二脱氧-1,5-亚氨基-1-甲基-D-山梨醇;N-甲基脱氧野尻霉素;N-甲基-1-脱氧尻霉素;N-甲基-1-脱氧野尻霉素;化合物 T12151;N-甲基-1-脱氧诺吉霉素;(2R,3R,4R,5S)-2-(羟甲基)-1-甲基哌啶-3,4,5-三醇;化合物 N-METHYLMORANOLINE |
| 英文名称 | N-METHYL-1-DEOXYNOJIRIMYCIN |
| 英文同义词 | 1,5-DIDEOXY-1,5-IMINO-1-METHYL-D-SORBITOL;N-METHYL-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL;N-METHYL-1-DEOXYNOJIRIMYCIN;N-METHYLDEOXYNOJIRIMYCIN;DEOXYNOJIRIMYCIN, N-METHYL-;(2R)-1-Methyl-2α-(hydroxymethyl)-3β,4α,5β-piperidinetriol;(2R)-2α-(Hydroxymethyl)-1-methyl-3β,4α,5β-piperidinetriol;MOR-14 |
| CAS号 | 69567-10-8 |
| 分子式 | C7H15NO4 |
| 分子量 | 177.2 |
| EINECS号 | 203-703-2 |
| 相关类别 | 13C & 2H Sugars;Carbohydrates & Derivatives;Glycosidase Inhibitors;Inhibitors |
| Mol文件 | 69567-10-8.mol |
| 结构式 |  |
丙二腈 性质
| 熔点 | 126-128°C |
|---|---|
| 沸点 | 367.2±42.0 °C(Predicted) |
| 密度 | 1.394±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 超声处理轻微溶于甲醇，轻微溶于水 |
| 酸度系数(pKa) | 13.71±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 生物来源 | synthetic (organic) |
| BRN | 1524564 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1 |
| InChIKey | AAKDPDFZMNYDLR-XZBKPIIZSA-N |
| SMILES | CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO |
N-Methylmoranoline dose-dependently decreases the α-1,6-glucosidase activity in rabbit heart extract. The myocardial uptake of a considerable amount of N-Methylmoranoline is sufficient to fully inhibit alpha-1,6-glucosidase. Preischemic treatment with 25, 50, and 100 mg/kg of N-Methylmoranoline dose-dependently reduces the infarct size without altering the blood pressure or heart rate. MOR-14 significantly increases levels of PKC-ε in the particulate fraction at 20 and 30 min of ischaemia and in the cytosolic fraction at 30 min of ischaemia.
N-Methylmoranoline decreases the alpha-1,6-glucosidase activity to approximately 20%, reduces the glycogen breakdown, and attenuates the lactate accumulation at both 10 and 30 minutes of ischemia. MOR-14 is protective against postischemic left ventricular dysfunction through the inhibition of glycogenolysis in the isolated rat heart.
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-U00090 | 丙二腈 N-Methylmoranoline | 69567-10-8 | 1 mg | 1818元 |
| 2025/12/22 | HY-U00090 | 丙二腈 N-Methylmoranoline | 69567-10-8 | 5mg | 4000元 |