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| | 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone Basic information |
| Product Name: | 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone | | Synonyms: | 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone;1-(4-Bromo-2-fluorophenyl)-2-bromo-1-ethanone;4-Bromo-2-fluorophenacyl bromide;Ethanone, 2-bromo-1-(4-bromo-2-fluorophenyl)-;2-Bromo-1-(4-bromo-2-fluorophenyl) | | CAS: | 869569-77-7 | | MF: | C8H5Br2FO | | MW: | 295.93 | | EINECS: | | | Product Categories: | | | Mol File: | 869569-77-7.mol |  |
| | 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone Chemical Properties |
| Boiling point | 306.7±32.0 °C(Predicted) | | density | 1.914±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | crystalline powder | | color | White |
| | 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone Usage And Synthesis |
| Synthesis | Step 3: A solution of 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone bromide (1.2 mL, 23.0 mmol) in 10 mL of glacial acetic acid was slowly added dropwise to a solution of 1-(4-bromo-2-fluorophenyl)ethanone (5.0 g, 23.0 mmol) in 150 mL of anhydrous methylene chloride, and the reaction was carried out at 0°C. After dropwise addition, the reaction mixture was slowly warmed up to room temperature. The progress of the reaction was monitored by TLC (unfolding agent: 5% ethyl acetate/hexane) to confirm complete consumption of the feedstock. The reaction mixture was diluted with dichloromethane and washed sequentially with 5% sodium thiosulfate solution and saturated saline. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone (6.6 g, 97% yield) as a light green oil. | | References | [1] Patent: US2008/45556, 2008, A1. Location in patent: Page/Page column 32-33
[2] Patent: WO2012/125926, 2012, A2. Location in patent: Page/Page column 79
[3] Patent: WO2012/122716, 2012, A1. Location in patent: Page/Page column 98
[4] Patent: CN107629023, 2018, A. Location in patent: Paragraph 0199; 0202; 0203; 0204
[5] Patent: CN107629022, 2018, A. Location in patent: Paragraph 0311; 0312; 0313; 0314 |
| | 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone Preparation Products And Raw materials |
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