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| | RNase H2B (C-Term) Rabbit Monoclonal Antibody (Clone RM433) Basic information |
| | RNase H2B (C-Term) Rabbit Monoclonal Antibody (Clone RM433) Chemical Properties |
| | RNase H2B (C-Term) Rabbit Monoclonal Antibody (Clone RM433) Usage And Synthesis |
| Description | RNase H2B is a non-catalytic accessory subunit of RNase H2, the major nuclear enzyme responsible for degrading RNA/DNA hybrids and hydrolyzing ribonucleotides misincorporated during genomic replication.1,2,3 It is localized to nuclear replication foci, where it forms a complex with RNase H2A and RNase H2C, and contains a C-terminal PIP-box motif that meditates its interaction with proliferating cell nuclear antigen (PCNA), which confirms strand specificity to RNase H2.3 Biallelic mutations in RNASEH2B induce Aicardi-Goutières syndrome (AGS), an autoimmune disorder characterized by constitutive activation of cGAS and IFN overproduction.4 Mutations in RNASEH2B are also associated with uncomplicated hereditary spastic paraplegia.5 Cayman’s RNase H2B (C-Term) Rabbit Monoclonal Antibody (Clone RM433) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use. |
| | RNase H2B (C-Term) Rabbit Monoclonal Antibody (Clone RM433) Preparation Products And Raw materials |
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