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| | 1,4-Dibromo-2,5-bis(brommethyl)benzene Basic information | | Uses |
| Product Name: | 1,4-Dibromo-2,5-bis(brommethyl)benzene | | Synonyms: | 1,4-Dibromo-2,5-bis(bromomethyl)benzene 97%;2,5-Bis(bromomethyl)-1,4-dibromobenzene 97%;4-(Bromomethyl)-2,5-dibromobenzyl bromide;alpha,alpha,2,5-Tetrabromo-p-xylene;2,5-Bis(Bromomethyl)-1,4-dibromobenzene;1,4-Bis(bromomethyl)-2,5-dibromobenzene97%;1,4-Bis(bromomethyl)-2,5-dibromobenzene 97%;1,4-Dibromo-2,5-bis(bromomethyl)benzene> | | CAS: | 35335-16-1 | | MF: | C8H6Br4 | | MW: | 421.75 | | EINECS: | 233-305-4 | | Product Categories: | blocks;Bromides | | Mol File: | 35335-16-1.mol |  |
| | 1,4-Dibromo-2,5-bis(brommethyl)benzene Chemical Properties |
| Melting point | 171-177℃ | | Boiling point | 392℃ | | density | 2.332 | | Fp | 185℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | color | White to Light yellow | | Sensitive | Lachrymatory |
| Hazard Codes | C | | RIDADR | 3261 | | Hazard Note | Corrosive/Lachrymatory | | HS Code | 2903998090 |
| | 1,4-Dibromo-2,5-bis(brommethyl)benzene Usage And Synthesis |
| Uses | 1,4-Dibromo-2,5-bis(bromomethyl)benzene is used as an organic and pharmaceutical intermediate. | | Synthesis | General procedure for the synthesis of 1,4-dibromo-2,5-bis(bromomethyl)benzene from 2,5-dibromo-1,4-dimethylbenzene: 2,5-dibromo-p-xylene (26.4 g, 0.1 mol) and N-bromosuccinimide (NBS, 39 g, 0.22 mol) were suspended in carbon tetrachloride (300 mL), and benzoyl peroxide (0.6 g) was added as the initiator. Prior to the start of the reaction, a nitrogen stream was passed through the bubble for 5 min to exclude oxygen. Subsequently, the reaction mixture was heated and refluxed in an oil bath at 100 °C for 2 hours. Upon completion of the reaction, ethanol (200 mL) was added to precipitate the product and the solid was collected by filtration. The solid was washed with ethanol (50 mL) to remove residual reactants and by-products and finally dried under vacuum to afford 1,4-dibromo-2,5-bis(bromomethyl)benzene as a white solid (13.36 g, 31.6% yield). The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3): δ 7.68 (s, 2H, aryl ring hydrogen), 4.50 (s, 4H, bromomethyl hydrogen). | | References | [1] Tetrahedron Letters, 2007, vol. 48, # 35, p. 6075 - 6079
[2] Organic and Biomolecular Chemistry, 2010, vol. 8, # 24, p. 5620 - 5627
[3] Journal of the American Chemical Society, 2017, vol. 139, # 45, p. 16210 - 16221
[4] Journal of the American Chemical Society, 2017, vol. 139, # 47, p. 17082 - 17088
[5] Journal of the American Chemical Society, 2009, vol. 131, # 49, p. 17724 - 17725 |
| | 1,4-Dibromo-2,5-bis(brommethyl)benzene Preparation Products And Raw materials |
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