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info@lynnchem.com |
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Novachemistry |
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| | REVEROMYCIN D Basic information |
| Product Name: | REVEROMYCIN D | | Synonyms: | REVEROMYCIN D;Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-3-pentyl-1,7-dioxaspiro[5.5]undec-3-yl] ester | | CAS: | 144860-70-8 | | MF: | C37H54O11 | | MW: | 674.82 | | EINECS: | | | Product Categories: | | | Mol File: | 144860-70-8.mol |  |
| | REVEROMYCIN D Chemical Properties |
| Boiling point | 855.3±65.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | White to tan solid. | | pka | 4.36±0.17(Predicted) |
| | REVEROMYCIN D Usage And Synthesis |
| Description | Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs = 2 and >500 μg/ml at pH 3 and 7.4, respectively). Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s = 1.6 and 1.3 μg/ml, respectively). | | Uses | Reveromycin D is the isopentyl analogue and a minor component of the reveromycin complex, isolated from a Streptomyces sp.. Published information on reveromycin D suggests that it is more active than its straight chain analogue, reveromycin C. | | Uses | Reveromycin D is a minor component of the reveromycin complex. | | References | [1] H TAKAHASHI. Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties.[J]. Journal of Antibiotics, 1992, 45 9: 1409-1413. DOI: 10.7164/antibiotics.45.1409
[2] H TAKAHASHI. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities.[J]. Journal of Antibiotics, 1992, 45 9: 1414-1419. DOI: 10.7164/antibiotics.45.1414 |
| | REVEROMYCIN D Preparation Products And Raw materials |
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