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| | 9alpha,11alpha-Methylene-15s-hydroxy-11a-deoxy-11a-methylene-thromba-5z,13e-dien-1-oic acid Basic information |
| | 9alpha,11alpha-Methylene-15s-hydroxy-11a-deoxy-11a-methylene-thromba-5z,13e-dien-1-oic acid Chemical Properties |
| Boiling point | 500.044±25.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.057±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 25 mg/ml; Ethanol: 100 mg/ml; PBS pH 7.2: 100 μg/ml | | pka | 4.761±0.10(predicted) |
| | 9alpha,11alpha-Methylene-15s-hydroxy-11a-deoxy-11a-methylene-thromba-5z,13e-dien-1-oic acid Usage And Synthesis |
| Description | Carbocyclic thromboxane A2 (CTA2) is a stable analog of TXA2. CTA2 is a potent coronary vasoconstrictor and is effective at concentrations as low as 1 nM in cat coronary arteries. Unlike other vascular TP receptor agonists, CTA2 is a potent inhibitor of prostanoid-induced platelet aggregation. It inhibits arachidonic acid-induced aggregation with an IC50 value of 4-5 μM. CTA2 also exhibits selective and dose-dependent inhibition of TXB2 synthesis in rabbit platelets at concentrations between 1 and 100 μM. | | Uses | Carbocyclic Thromboxane A2 is a stable analog of TXA2 which inhibits thromboxane-mediated vasoconstriction platelet aggregation. Also, it converts the thromboxane synthase (TXAS) heme cofactor to its 5-coordinate. |
| | 9alpha,11alpha-Methylene-15s-hydroxy-11a-deoxy-11a-methylene-thromba-5z,13e-dien-1-oic acid Preparation Products And Raw materials |
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