1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride

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1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride manufacturers

  • HA-100
  • HA-100 pictures
  • $57.00
  • 2026-07-14
  • CAS:84468-24-6
  • Purity: 99.69%
  • Supply Ability: 10g
1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride Basic information
Product Name:1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride
Synonyms:1-(5-isoquinolinylsulfonyl)-piperazin;1-(5-isoquinolinylsulfonyl)piperazine;1-(5-ISOQUINOLINYLSULFONYL)PIPERAZINE 2HCL;1-(5-ISOQUINOLINYLSULFONYL)-PIPERAZINE HYDROCHLORIDE;1-(5-ISOQUINOLINESULFONYL)PIPERAZINE;C-1;HA-100;HA-100 DIHYDROCHLORIDE
CAS:84468-24-6
MF:C13H15N3O2S
MW:277.34
EINECS:
Product Categories:Protein Kinase Inhibitors and Activators;Protein Kinase
Mol File:84468-24-6.mol
1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride Structure
1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride Chemical Properties
Melting point >240°C (dec.)
Boiling point 497.4±55.0 °C(Predicted)
density 1.332±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO, Methanol, Water
form Off-white lyophilized solid.
pka7.66±0.10(Predicted)
color Off-White to Pale Yellow
InChI1S/C13H15N3O2S.2ClH/c17-19(18,16-8-6-14-7-9-16)13-3-1-2-11-10-15-5-4-12(11)13;;/h1-5,10,14H,6-9H2;2*1H
InChIKeyZKQAPKKKTQCVKG-UHFFFAOYSA-N
SMILES[H]Cl.[H]Cl.O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O
CAS DataBase Reference84468-24-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS TM0862600
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
ProviderLanguage
SigmaAldrich English
1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride Usage And Synthesis
Chemical PropertiesPale Yellow Crystalline Solid
UsesExhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases
DefinitionChEBI: 5-(1-piperazinylsulfonyl)isoquinoline is a member of isoquinolines.
Biological ActivityInhibitor of protein kinase C. Vasodilator.
IC 50PKC: 12 μM (IC50); PKG: 4 μM (IC50); PKA: 8 μM (IC50); MLCK: 240 μM (IC50); PKC: 6.5 μM (Ki); MLCK: 61 μM (Ki)
1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride Preparation Products And Raw materials
Raw materialsIsoquinoline-5-sulfonyl chloride-->Isoquinoline-5-sulphonyl chloride hydrochloride-->Piperazine-->1-BOC-Piperazine
Tag:1-(5-Isoquinolinesulfonyl)piperazine, dihydrochloride(84468-24-6) Related Product Information
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