Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- manufacturers
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| | Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Basic information |
| | Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Chemical Properties |
| Melting point | 60-62° | | Boiling point | 363.5±52.0 °C(Predicted) | | density | 1.357±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform, Methanol | | form | Solid | | pka | 1.62±0.10(Predicted) | | color | Yellow |
| HazardClass | IRRITANT | | HS Code | 2934100090 |
| | Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Uses | Intermediate in the production of GW 501516 and its derivatives | | Synthesis | To a stirred solution of Intermediate 1 (8.2 g, 30 mmol) and triethylamine (6.07 g, 8.36 mL, 60 mmol) in anhydrous dichloromethane (120 mL) at 0 °C was slowly added methanesulfonyl chloride (5.49 g, 3.71 mL, 48 mmol). After 2 hours of reaction at 0°C, additional triethylamine (6 mmol) and methanesulfonyl chloride (4.8 mmol) were added. After 2 hours of reaction, thin layer chromatography (TLC, unfolding agent: hexane/ethyl acetate, 1:1) showed complete reaction. The reaction mixture was diluted with dichloromethane (120 mL) and washed sequentially with saturated sodium bicarbonate solution (2 x 240 mL) and water (2 x 240 mL), and the organic phase was dried, filtered, and concentrated to afford 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (8.0 g, 27 mmol, 90% yield) as a yellow solid. | | References | [1] Patent: WO2004/785, 2003, A2. Location in patent: Page 43 |
| | Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials |
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