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| | Ammonium 1-pyrrolidinedithiocarbamate Basic information |
| Product Name: | Ammonium 1-pyrrolidinedithiocarbamate | | Synonyms: | 1-Pyrrolidinecarbodithioic acid, ammonium salt,95%;Ammonium Pyrrolidine-N-dithiocarba;PDTC Pyrrolidinedithiocarbamate, ammonium derivative;Ammonium pyrrolidinedithiocarbamate,1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC;Ammonium pyrrolidine;1-Pyrrolidinecarbodithioic acid, aMMoniuM salt, 98% 25GR;Ammonium Pyrrolidine-N-dithiocarbamate
1-Pyrrolidinecarbodithioic Acid Ammonium Salt
Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMO | | CAS: | 5108-96-3 | | MF: | C5H9NS2.H3N | | MW: | 164.3 | | EINECS: | 225-834-4 | | Product Categories: | Nitric Oxide;5108-96-3 | | Mol File: | 5108-96-3.mol |  |
| | Ammonium 1-pyrrolidinedithiocarbamate Chemical Properties |
| Melting point | 153-155 °C(lit.) | | density | 1.117 (estimate) | | bulk density | 400kg/m3 | | refractive index | 1.5300 (estimate) | | storage temp. | Store at +2°C to +8°C. | | solubility | 190g/l | | form | Powder/Solid | | color | White to off-white | | PH | 6-7 (50g/l, H2O, 20℃) | | biological source | microbial | | Water Solubility | 50 g/L (20 ºC) | | Sensitive | Hygroscopic | | BRN | 3730472 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3 | | InChIKey | MDDIUTVUBYEEEM-UHFFFAOYSA-N | | SMILES | N.SC(=S)N1CCCC1 | | CAS DataBase Reference | 5108-96-3(CAS DataBase Reference) | | EPA Substance Registry System | 1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | F | 3 | | TSCA | TSCA listed | | HS Code | 29339990 | | Storage Class | 11 - Combustible Solids |
| | Ammonium 1-pyrrolidinedithiocarbamate Usage And Synthesis |
| Description | Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 μM). At 300 μM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application. In vascular smooth muscle cells, PDTC (10 μM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway. PDTC (100 μM) also has antioxidant properties. | | Chemical Properties | pale yellow crystalline solid | | Uses | Ammonium pyrrolidinedithiocarbamate has been used:
- to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
- to reduce neutrophil activity in rats
- to prevent Ca2+ influx in adriamycin (ADR)-treated podocytes
to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells | | Uses | 1-Pyrrolidinecarbodithioic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; | | General Description | Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells. | | Biochem/physiol Actions | Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. | | Purification Methods | Purify the salt by recrystallising twice by dissolving in MeOH and adding Et2O. It has also been purified by recrystallisation from EtOH. It is used for the precipitation of As, Bi, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Su, V and Zn from acidic solutions [Kinrade & van Loon Anal Chem 46 1894 1974]. The ethyl ester has b 87-89o/0.01mm. [Synthesis and Polarography: Kitagawa & Taku Bull Chem Soc Jpn 64 2151 1973, Malissa & Sch.ffmann Mikrochim Acta 187 1955, Beilstein 20 III/IV 195, 20/1 V 331.] | | References | [1] R SCHRECK. Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.[J]. Journal of Experimental Medicine, 1992, 175 5: 1181-1194. DOI: 10.1084/jem.175.5.1181
[2] H. ZIEGLER-HEITBROCK. Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.[J]. Journal of immunology, 1993, 151 12 1: 6986-6993. DOI: 10.4049/jimmunol.151.12.6986
[3] SUNG-KWON MOON. PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: Involvement of p38 mitogen activated protein kinase[J]. Journal of Cellular Physiology, 2003, 198 2: 310-323. DOI: 10.1002/jcp.10728
[4] SUOWEN XU . Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation[J]. Translational Research, 2012, 160 2: Pages 114-124. DOI: 10.1016/j.trsl.2012.01.008 |
| | Ammonium 1-pyrrolidinedithiocarbamate Preparation Products And Raw materials |
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