3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride

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3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride manufacturers

  • SB 258719
  • SB 258719 pictures
  • $50.00
  • 2026-07-27
  • CAS:195199-95-2
  • Purity: 99.73%
  • Supply Ability: 10g
  • SB 258719
  • SB 258719 pictures
  • $50.00
  • 2026-07-27
  • CAS:195199-95-2
  • Purity: 99.73%
  • Supply Ability: 10g
3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride Basic information
Product Name:3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride
Synonyms:SB 258719;SB 258719 HYDROCHLORIDE;Benzenesulfonamide, N,3-dimethyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-;SB-258719 >=98% (HPLC);5-HT Receptor,5-hydroxytryptamine Receptor,agonism,SB258719,Inhibitor,inverse,hydrochloride,partial,SB 258719,SB-258719,apparent,selective,inhibit,Serotonin Receptor,affinity;SB 258719, 10 mM in DMSO;3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride
CAS:195199-95-2
MF:C18H30N2O2S
MW:338.51
EINECS:
Product Categories:
Mol File:195199-95-2.mol
3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride Structure
3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride Chemical Properties
Boiling point 463.6±55.0 °C(Predicted)
density 1.075±0.06 g/cm3(Predicted)
storage temp. Desiccate at RT
solubility DMSO: 250 mg/mL (738.53 mM)
pka9.36±0.10(Predicted)
form Liquid
color Light yellow to yellow
InChI1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3
InChIKeyAGVNHDNTFYHZNL-UHFFFAOYSA-N
SMILESCC1=CC=CC(S(N(C)[C@H](C)CCN2CCC(C)CC2)(=O)=O)=C1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride Usage And Synthesis
UsesSB 258719 Hydrochloride is a useful intermediate.
Biological ActivitySelective 5-HT 7 receptor antagonist that displays > 100-fold selectivity over a range of other receptors. Reverses the hypothermic effect of 5-CT in mice following i.p. administration.
in vivo

SB 258719 (5-20 mg/kg; i.p.) significantly attenuates the 5-CT-induced hypothermia[2].

Animal Model:Male Swiss Webster mice (20-25 g)[2].
Dosage:5-20 mg/kg
Administration:I.p.
Result:Significantly attenuated the 5-CT-induced hypothermia.
IC 505-HT7 Receptor: 7.5 (pKi)
3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride Preparation Products And Raw materials
Tag:3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride(195199-95-2) Related Product Information
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