Furo[2,3-c]pyridine-2-carboxylic acid

138173-83-8

112372-15-3

General procedure for the synthesis of furo[2,3-c]pyridine-2-carboxylic acid from ethyl furo[2,3-c]pyridine-2-carboxylate: ethyl furo[2,3-c]pyridine-2-carboxylate (3.82 g, 19.98 mmol) was dissolved in a mixed solvent of THF:MeOH (1:1, 6.4 mL) and potassium hydroxide (3.36 g, 59.9 mmol). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the solvent was concentrated under reduced pressure to about 20 mL and the pH was subsequently adjusted with acetic acid to about 4. The precipitated solid product was collected by vacuum filtration, washed twice with water, and dried overnight in a vacuum oven to afford furano[2,3-c]pyridine-2-carboxylic acid (2.90 g, 89% yield). The product was characterized by 1H NMR (DMSO-d6): δ 9.09 (s, 1H), 8.47 (d, 1H), 7.81 (dd, 1H), 7.71 (d, 1H), 3.36 (br s, 1H).