| Company Name: |
Suzhou Devi Pharmaceutical Technology Co., Ltd Gold
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| Tel: |
18651107528 18651107528 |
| Email: |
sales@dvpharm.com |
| Products Intro: |
Product Name:5-amino-3-chloropicolinonitrile
CAS:488713-31-1
Purity:97% Package:5g; 25g; 100g; 1kg
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| | 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- Basic information |
| | 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | Appearance | Light brown to brown Solid |
| | 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- Usage And Synthesis |
| Synthesis | (Step 3) (1068) 3-Chloro-5-nitropyridine-2-carbonitrile (0.18 g, 0.984 mmol) was dissolved in ethanol (6.0 mL), and stannic chloride (II) (0.929 g, 4.918 mmol) was added. The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, it was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate to 7. The reaction mixture was extracted with ethyl acetate (3×), the organic layer was washed sequentially with water and saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give 5-amino-3-chloropyridine-2-carbonitrile (0.13 g, 87% yield) as an off-white solid.1H-NMR (400 MHz, DMSO-d6): δ 6.77 (broad single peak, 2H), 7.05 (d, 1H, J=2.32 Hz), 7.94 (d, 1H, J=2.28 Hz). | | References | [1] Patent: EP2975031, 2016, A1. Location in patent: Paragraph 1068
[2] Patent: EP3192791, 2017, A1. Location in patent: Paragraph 0507
[3] Patent: WO2004/50637, 2004, A2. Location in patent: Page 66-67
[4] Patent: US2003/114457, 2003, A1 |
| | 2-PYRIDINECARBONITRILE, 5-AMINO-3-CHLORO- Preparation Products And Raw materials |
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