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| | 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Basic information |
| | 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties |
| density | 1.654 | | storage temp. | Sealed in dry,Room Temperature | | pka | 13.49±0.40(Predicted) | | form | powder | | color | Yellow | | InChI | 1S/C8H7BrN2/c1-5-2-6-3-7(9)4-10-8(6)11-5/h2-4H,1H3,(H,10,11) | | InChIKey | IWLFWGLFINYFHA-UHFFFAOYSA-N | | SMILES | Cc1cc2cc(Br)cnc2[nH]1 |
| Hazard Codes | Xn | | Risk Statements | 22-41 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids |
| | 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Usage And Synthesis |
| Synthesis | Preparation of Method A Steps for the synthesis of intermediate 4: 5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine: Ingredient 3 (88 mg, 0.251 mmol) was dissolved in methanol (4 mL), 2 N sodium hydroxide solution (1 mL) was added, and the reaction mixture was heated and refluxed for 2 hours. After completion of the reaction, ethyl acetate was added for extraction and the organic phase was washed sequentially with 1 N sodium hydroxide solution and water. Purification by silica gel column chromatography (slow gradient elution, volume fraction of methanol in dichloromethane increased from 0% to 2%) afforded the target product 4 (40 mg, 0.19 mmol, 76% yield). Product characterization data were as follows: 1H NMR (CDCl3, 300 MHz): δ 10.26 (br s, 1H), 8.22 (d, J = 2.1 Hz, 1H), 8.92 (d, J = 2.1 Hz, 1H), 6.13 (s, 1H), 2.52 (s, 3H). MS (m/z): 210 (M + H). | | References | [1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 5, p. 582 - 586
[2] Patent: WO2011/149950, 2011, A2. Location in patent: Page/Page column 151-152
[3] Patent: WO2014/85795, 2014, A1. Location in patent: Paragraph 0394
[4] Bioorganic Chemistry, 2016, vol. 65, p. 146 - 158
[5] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 74 |
| | 5-Bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials |
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