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| | Sancycline hydrochloride Basic information |
| Product Name: | Sancycline hydrochloride | | Synonyms: | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4A,5,5A,6,11,12A-octahydro-3,10,12,12A-tetrahydroxy-1,11-dioxo-, monohydrochloride, [4S-(4.alpha.,4A.alpha.,5A.alpha.,12A.alpha.)]-;2-Naphthacenecarboxamide, 4-dimethylamino-1,4,4A,5,5A,6,11,12A-octahydro-3,10,12,12A-tetrahydroxy-1,11-dioxo-, hydrochloride;Bonomycin hydrochloride;Fda 0129;(4S,4aS,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1-11-dioxo-2-naphthacenecarboxaMide Hydrochloride;6-DeMethyl-6-deoxytetracycline Hydrochloride;Minocycline EP IMpurity B;6-DeMethyl-6-deoxytetracycline hydrochloride, NSC 51812 | | CAS: | 6625-20-3 | | MF: | C21H22N2O7.ClH | | MW: | 450.87 | | EINECS: | | | Product Categories: | Amines;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 6625-20-3.mol |  |
| | Sancycline hydrochloride Chemical Properties |
| Melting point | 224-2280C (dec.) | | storage temp. | -20°C Freezer | | solubility | DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:5): 0.15 mg/mL; Ethanol: 5mg/mL | | form | A crystalline solid | | color | White to off-white |
| | Sancycline hydrochloride Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Uses | Sancycline hydrochloride is the hydrochloride salt of a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. | | Uses | Sancycline Hydrochloride (Minocycline EP Impurity B) is a semi-synthetic antibiotic related to Tetracycline. | | IC 50 | Tetracycline |
| | Sancycline hydrochloride Preparation Products And Raw materials |
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