2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine

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2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine manufacturers

  • S107
  • S107 pictures
  • $32.00
  • 2026-08-07
  • CAS:927871-76-9
  • Purity: 99.90%
  • Supply Ability: 10g
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Basic information
Product Name:2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine
Synonyms:2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine;S-107; S 10;CS-2452;7-methoxy-4-methyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepine;2,3,4,5-Tetrahydro-7-methoxy-4-methyl-;S 107 hydrochloride;1,4-Benzothiazepine, 2,3,4,5-tetrahydro-7-methoxy-4-methyl-;S107 free base
CAS:927871-76-9
MF:C11H15NOS
MW:209.31
EINECS:
Product Categories:API
Mol File:927871-76-9.mol
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Structure
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Chemical Properties
Boiling point 318.8±42.0 °C(Predicted)
density 1+-.0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 100mg/mL
pka7.74±0.20(Predicted)
form Solid
color White to off-white
Water Solubility Water : ≥ 132 mg/mL (537.09 mM)
BRN 18342799
InChIKeyBGVCEGVSQDOGSB-UHFFFAOYSA-N
SMILESS1CCN(Cc2c1ccc(c2)OC)C
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Usage And Synthesis
UsesIt is a benzothiazepine derivative that binds the RyR1 channel and enhances the binding affinity of Calstabin-1. By preventing the depletion of Calstabin-1 from the RyR1 complex, S 107 slows muscle fatique and reduces muscle damage in exercised mice. In a murine model of Duchenne muscular dystrophy, S 107 reduces biochemical and histological evidence of the muscle damage associated with muscular dystrophy, improves muscle function, and increases exercise performance.
Biological ActivityPrimary Target
RyR2
in vivo

S107, which prevents a leak in the channel but does not block the channel or alter normal Ca2+ signaling, is able to inhibit both seizures and arrhythymias in the mutant mice[1].

2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine Preparation Products And Raw materials
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