A 1120 manufacturers
- A 1120
-
- $38.00
-
2026-07-17
- CAS:1152782-19-8
- Purity: 99.47%
- Supply Ability: 10g
- A 1120
-
- $38.00
-
2026-07-17
- CAS:1152782-19-8
- Purity: 99.47%
- Supply Ability: 10g
- A 1120
-
- $38.00
-
2026-07-17
- CAS:1152782-19-8
- Purity: 99.47%
- Supply Ability: 10g
|
| Product Name: | A 1120 | | Synonyms: | A 1120;2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid;Benzoic acid, 2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-;A-1120,Inhibitor,inhibit,A 1120,A1120;2-({4-[2-(trifluoromethyl)phenyl]piperidine-1-carbonyl}amino)benzoic acid;A 1120, 10 mM in DMSO | | CAS: | 1152782-19-8 | | MF: | C20H19F3N2O3 | | MW: | 392.37 | | EINECS: | | | Product Categories: | | | Mol File: | 1152782-19-8.mol |  |
| | A 1120 Chemical Properties |
| Boiling point | 572.3±50.0 °C(Predicted) | | density | 1.370±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: 100 mM; Ethanol: 25 mM | | form | powder | | pka | 4.03±0.36(Predicted) | | color | off-white | | InChI | 1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27) | | InChIKey | MEAQCLPMSVEOQF-UHFFFAOYSA-N | | SMILES | OC(=O)c1ccccc1NC(=O)N2CCC(CC2)c3ccccc3C(F)(F)F |
| Hazard Codes | Xn,N | | Risk Statements | 22-36-43-50/53 | | Safety Statements | 26-36/37-60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1
Eye Irrit. 2
Skin Sens. 1 |
| | A 1120 Usage And Synthesis |
| Uses | A 1120 is a a nonretinoid RBP4 antagonist, which inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. | | Biochem/physiol Actions | A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance. | | storage | Store at RT |
| | A 1120 Preparation Products And Raw materials |
|