CID 5951923
| 中文名称 | CID 5951923 |
|---|---|
| 中文同义词 | 3-(3-硝基苯基)-2-丙烯酸2-[甲基(四氢-1,1-二氧代-3-噻吩基)氨基] -2-氧代乙基酯;化合物 T22667;化合物CID 5951923;化合物CID 5951923,10 MM DMSO 溶液 |
| 英文名称 | CID 5951923 |
| 英文同义词 | CID 5951923;3-(3-Nitrophenyl)-2-propenoic Acid 2-[Methyl(tetrahydro-1,1-dioxido-3-thienyl)aMino]-2-oxoethyl Ester;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-methyl ester;[2-[(1,1-Dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate;AC1NZ6UQ;3-(3-Nitro-phenyl)-acrylic acid [(1,1-dioxo-tetrahydro-1l6-thiophen-3-yl)-methyl-carbamoyl]-me;KLF5 Inhibitor, CID 5951923;KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem |
| CAS号 | 749872-43-3 |
| 分子式 | C16H18N2O7S |
| 分子量 | 382.39 |
| EINECS号 | |
| 相关类别 | Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 749872-43-3.mol |
| 结构式 |  |
CID 5951923 性质
| 沸点 | 646.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.43±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO：可溶10mg/mL（澄清溶液） |
| 形态 | 粉末 |
| 酸度系数(pKa) | -1.40±0.20(Predicted) |
| 颜色 | 白色至米色 |
| InChI | 1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+ |
| InChIKey | URVRJYLSUVXWBC-AATRIKPKSA-N |
| SMILES | O=C(OCC(N(C)C1CS(CC1)(=O)=O)=O)/C=C/C2=CC=CC([N+]([O-])=O)=C2 |
CID 5951923是一种有效的 Krüppel-like factor 5 (KLF5) 抑制剂，IC50 值为 603 nM，CID 5951923 可在体外抑制癌细胞的增殖。
IC50: 603 nM (KLF5)
CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner.
CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY
1068
, and downregulated EGR1.
CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells.
Cell Viability Assay
| Cell Line: | DLD-1 and IEC-6 cells |
| Concentration: | 0.001, 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time: | 48 h |
| Result: | Inhibited proliferation of DLD-1 cells with an IC 50 of 1.6 μM. |
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |