NEUROPEPTIDE Y (3-36) (PORCINE)

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NEUROPEPTIDE Y (3-36) (PORCINE) Basic information
Product Name:NEUROPEPTIDE Y (3-36) (PORCINE)
Synonyms:H-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-LEU-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2;neuropeptide Y fragment 3-36;NEUROPEPTIDE Y FRAGMENT 3-36, HUMAN,*POR CINE;SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-LEU-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2;SKPDNPGEDAPAEDLARYYSALRHYINLITRQRY-NH2;NEUROPEPTIDE Y (3-36) (PORCINE);NEUROPEPTIDE Y FRAGMENT 3-36 PORCINE;NPY (3-36) (PORCINE)
CAS:143863-88-1
MF:C176H271N53O54
MW:3993.36
EINECS:
Product Categories:Neuropeptide YPeptides for Cell Biology;Y Receptor Ligands;Gastrointestinal Peptides;Neuropeptide Y and Peptide YY Peptides;Neuropeptide YNeuropeptides;Obesity Peptides;Peptides for Cell Biology;peptide
Mol File:Mol File
NEUROPEPTIDE Y (3-36) (PORCINE) Structure
NEUROPEPTIDE Y (3-36) (PORCINE) Chemical Properties
storage temp. −20°C
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
NEUROPEPTIDE Y (3-36) (PORCINE) Usage And Synthesis
UsesNeuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36[1][2][3].
in vivo

Neuropeptide Y (3-36) (porcine) (0.24-24 nM; i.c.v.; single dose) induces feeding in the rat in a dose-dependent manner[1].
Neuropeptide Y (3-36) (porcine) (4 μg, 8 μg; i.c.v.; single dose) significantly increased food intake at 2 and 3 h, results dose-dependently orexigenic effect in rainbow trout (Oncorhynchus mykiss)[2].

Animal Model:Adult male Wistar rats (250-300 g)[1]
Dosage:0.24, 0.72, 2.4, 7.2, 24 nM per animal
Administration:Intracerebroventricular injection; single dose
Result:Stimulated rat feeding dose-dependently.
Produced no feeding effect alone, that Y2 activation alone elicited no feeding response.
IC 50NPY Y2 receptor
References[1] O'Shea D, et al. Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology. 1997 Jan;138(1):196-202. DOI:10.1210/endo.138.1.4899
[2] Grandt D, et al. Neuropeptide Y 3-36 is an endogenous ligand selective for Y2 receptors. Regul Pept. 1996 Nov 14;67(1):33-7. DOI:10.1016/s0167-0115(96)00104-8
[3] M Aldegunde, et al. Effects of neuropeptide Y on food intake and brain biogenic amines in the rainbow trout (Oncorhynchus mykiss), Peptides. 2006; 27(4):719-727. DOI:10.1016/j.peptides.2005.09.014
NEUROPEPTIDE Y (3-36) (PORCINE) Preparation Products And Raw materials
Tag:NEUROPEPTIDE Y (3-36) (PORCINE)(143863-88-1) Related Product Information
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