ChemicalBook > Product Catalog >Petrochemical >Oils >17(S)-HDoHE

17(S)-HDoHE

Request For Quotation
17(S)-HDoHE Suppliers list
Company Name: Yichang Zhongyitai Trading Co., Ltd.  
Tel: 0717-6449896 13886658719
Email: root@zhongyitai.com
Company Name: Shanghai Macklin Biochemical Co.,Ltd.  
Tel: 15221275939 15221275939
Email: shenlinxing@macklin.cn
Company Name: Alfa Chemistry  
Tel: 1-516-6625404
Email: support@alfa-chemistry.com
Company Name: Shanghai Qiao Chemical Science Co., Ltd  
Tel: 021-58892003
Email: info@qiaochem.com
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774 400-920-5774
Email: sales@glpbio.cn

17(S)-HDoHE manufacturers

  • 17(S)-HDHA
  • 17(S)-HDHA pictures
  • $1970.00
  • 2026-07-27
  • CAS:92693-03-3
  • Purity:
  • Supply Ability: 10g
17(S)-HDoHE Basic information
Product Name:17(S)-HDoHE
Synonyms:17(S)-HDoHE;SWTYBBUBEPPYCX-YTQNUIGOSA-N;4,7,10,13,15,19-Docosahexaenoic acid, 17-hydroxy-, (4Z,7Z,10Z,13Z,15E,17S,19Z)-;17(S)-hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid;17(S)HDHA,17(S) HDHA;17(S)-Hydroxy-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA;17(S)-HDHA(solution in ethanol);17(S)-HDHA
CAS:92693-03-3
MF:C22H32O3
MW:344.49
EINECS:
Product Categories:
Mol File:92693-03-3.mol
17(S)-HDoHE Structure
17(S)-HDoHE Chemical Properties
Boiling point 505.091±50.00 °C(Press: 760.00 Torr)(predicted)
density 0.996±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. Store at -20°C
solubility DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka4.581±0.10(predicted)
form ethanol solution
InChIKeySWTYBBUBEPPYCX-YTQNUIGOSA-N
SMILESCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O
Safety Information
WGK Germany WGK 1
Storage Class3 - Flammable liquids
Hazard ClassificationsEye Irrit. 2
Flam. Liq. 2
MSDS Information
17(S)-HDoHE Usage And Synthesis
Description17(S)-HDHA is a hydroxy fatty acid formed from docosahexaenoic acid (DHA; ) by 15-lipoxygenase (15-LO) and is a precursor to 17(S)-resolvins.1,2 17(S)-HDHA inhibits platelet 12-LO (IC50 = 0.4 μM).2 It inhibits TNF-α-induced expression of IL1B in a human glial cell line (IC50 = ~0.5 nM).1 17(S)-HDHA (100 nM) inhibits NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome formation induced by homocysteine in podocytes.3
Uses17(S)-HDHA is a pro-resolving mediator (SPM). 17(S)-HDHA slightly activats PPARγ, PPARα and PPARδ[1].
DefinitionChEBI: 17(S)-HDoHE is a polyunsaturated fatty acid that is (4Z,7Z,10Z,13Z,15E,19Z)-docosa-4,7,10,13,15,19-hexaenoic acid carrying a hydroxy substituent at the 17S-position. It is a metabolite of docosahexaenoic acid in human blood and mouse brain, and serves as a precursor to 17(S)-resolvins. It has a role as a mouse metabolite, an animal metabolite and a human xenobiotic metabolite. It is an enantiomer of a 17(R)-HDoHE.
References1. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation J. Biol. Chem. 278(17),14677-14687(2003).
2. Mitchell, P.D., Hallam, C., Hemsley, P.E., et al. Inhibition of platelet 12-lipoxygenase by hydroxy-fatty acids Biochem. Soc. Trans. 12,839-841(1984).
3. Li, G., Chen, Z., Bhat, O.M., et al. NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury J. Lipid Res. 58(6),1080-1090(2017).
17(S)-HDoHE Preparation Products And Raw materials
Preparation Products17-keto-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
Tag:17(S)-HDoHE(92693-03-3) Related Product Information
14(S)-Hydroxy Docosahexaenoic Acid 17(S)-HDHA-d5 14(S)-HDHA-d5 17(S)-HDHA-d5 ethyl ester 17(R)-HDOHE Astaxanthin