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BIOSWAMP CO LTD |
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027-85586319 0278558631 |
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bio-swampname@qq.com |
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| | AIF Polyclonal Antibody Basic information |
| | AIF Polyclonal Antibody Chemical Properties |
| | AIF Polyclonal Antibody Usage And Synthesis |
| Description | Apoptosis-inducing factor (AIF) is a highly conserved mitochondrial protein with roles in redox-biochemistry and apoptosis. Apoptosis is a controlled process of cell death necessary for proper physiological development and maintenance. Loss of mitochondrial membrane potential results in the release of several proteins critical to the acceleration of apoptosis. When AIF is released from the mitochondrial intermembrane space it migrates to the nucleus to initiate chromatin condensation and DNA cleavage. AIF is recognized by immunoblotting at 67 kDa in most tissues and cell lines. | | References | [1] HANS KRISTIAN LORENZO. Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death[J]. Cell Death and Differentiation, 1999, 6 6: 516-524. DOI: 10.1038/sj.cdd.4400527
[2] NICHOLAS JOZA. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death[J]. Nature, 2001, 410 6828: 549-554. DOI: 10.1038/35069004
[3] GHOSH N, SIL P. Mitochondria and apoptosis[J]. Mitochondrial Physiology and Vegetal Molecules, 1900, 36 1: 0. DOI: 10.1016/b978-0-12-821562-3.00031-9
[4] SANTOS A. SUSIN. Molecular characterization of mitochondrial apoptosis-inducing factor[J]. Nature, 1999, 397 6718: 441-446. DOI: 10.1038/17135
[5] S A SUSIN. Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.[J]. Journal of Experimental Medicine, 1996, 184 4: 1331-1341. DOI: 10.1084/jem.184.4.1331
[6] E DAUGAS. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis.[J]. FASEB Journal, 2000, 14 5: 729-739.
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| | AIF Polyclonal Antibody Preparation Products And Raw materials |
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