CAY10526 manufacturers
- CAY10526
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2026-05-18
- CAS:938069-71-7
- Min. Order: 1kg
- Purity: 98%
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| | CAY10526 Basic information |
| Product Name: | CAY10526 | | Synonyms: | CAY10526;CAY10526 Exclusive;3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one;2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-;WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one;CAY10526, 10 mM in DMSO;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one | | CAS: | 938069-71-7 | | MF: | C12H7BrO3S | | MW: | 311.15 | | EINECS: | | | Product Categories: | | | Mol File: | 938069-71-7.mol |  |
| | CAY10526 Chemical Properties |
| Boiling point | 561.7±50.0 °C(Predicted) | | density | 1.889±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml | | form | A crystalline solid | | pka | 8.90±0.60(Predicted) | | color | Off-white to yellow | | InChI | 1S/C12H7BrO3S/c13-10-9(11(14)16-12(10)15)8-5-6-3-1-2-4-7(6)17-8/h1-5,11,14H | | InChIKey | ICCDILPNCJIDAW-UHFFFAOYSA-N | | SMILES | O=C1OC(C(C2=CC3=C(S2)C=CC=C3)=C1Br)O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | CAY10526 Usage And Synthesis |
| Description | Prostaglandin E2 (PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1). CAY10526 is an inhibitor of PGE2 production through the selective modulation of mPGES-1 expression. It dose-dependently inhibits PGE2 production in lipopolysaccharide-stimulated RAW 264.7 cells with an IC50 value of 1.8 μM without any effect on COX-2 expression. | | Uses | CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1[1]. | | References | [1] Sun-Hee Kim, et al. Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. Pigment Cell Melanoma Res. 2016 May;29(3):297-308. DOI:10.1111/pcmr.12455 |
| | CAY10526 Preparation Products And Raw materials |
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