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| | 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Basic information |
| Product Name: | 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- | | Synonyms: | 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel-;Trans-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;rel-Boc-Hyp-OMe;N-Boc-trans-4-hydroxy-proline methyl ester;trans-1-Boc-4-hydroxypyrolidine-2-carboxylic acidmethyl ester | | CAS: | 1145663-09-7 | | MF: | C11H19NO5 | | MW: | 245.27 | | EINECS: | | | Product Categories: | | | Mol File: | 1145663-09-7.mol |  |
| | 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Chemical Properties |
| Boiling point | 335.2±42.0 °C(Predicted) | | density | 1.216±0.06 g/cm3(Predicted) | | pka | 14.27±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Usage And Synthesis |
| Uses | rel-Boc-Hyp-OMe is the isomer of Boc-Hyp-OMe (HY-65039), and can be used as an experimental control. Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2R,4S)-rel- Preparation Products And Raw materials |
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