1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE CAS#: 1125758-85-1

1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE

生物活性靶点体外研究体内研究用途与合成方法 MSDS 1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE价格(试剂级) 上下游产品信息

中文名称	1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE
中文同义词	A-804598游离态;化合物CZC25146;S-2-氰基-1-(1-苯乙基)-3-(喹啉-5-基)胍;A 804598,P2X7拮抗剂;化合物A804598,10 MM DMSO 溶液;A 804598【CAS:1125758-85-1】【规格:1ml】【纯度:10mM in DMSO】;抑制剂A-804598;A-804598 ,S8725
英文名称	A 804598
英文同义词	A 804598;N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine;1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine;2-Cyano-1-[(1S)-1-phenylethyl]-3-(5-quinolinyl)guanidine;A-804598 （(A 804598;CS-2234;Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-;S-2-Cyano-1-(1-phenylethyl)-3-(quinolin-5-yl)guanidine
CAS号	1125758-85-1
分子式	C19H17N5
分子量	315.37
EINECS号
相关类别
Mol文件	1125758-85-1.mol
结构式

1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 性质

沸点	498.0±47.0 °C(Predicted)
密度	1.17±0.1 g/cm3(Predicted)
储存条件	Keep in dark place,Sealed in dry,2-8°C
溶解度	DMSO：可溶10mg/mL，澄清
酸度系数(pKa)	4.52±0.12(Predicted)
形态	粉末
颜色	白色至米色
InChI	1S/C19H17N5/c1-14(15-7-3-2-4-8-15)23-19(22-13-20)24-18-11-5-10-17-16(18)9-6-12-21-17/h2-12,14H,1H3,(H2,22,23,24)/t14-/m0/s1
InChIKey	PQYCRDPLPKGSME-AWEZNQCLSA-N
SMILES	N(c2c3c(nccc3)ccc2)\C(=N/[C@@H](C)c1ccccc1)\NC#N

1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 用途与合成方法

生物活性

A-804598 是一个 CNS 渗透，竞争性和选择性的 P2X7 受体拮抗剂，作用于小鼠，大鼠和人的 P2X7 受体，IC50s 分别是 9 nM, 10 nM 和 11 nM。

靶点

IC50: 9 nM (mouse P2X7 receptor), 10 nM (rat P2X7 receptor), 11 nM (human P2X7 receptor)

体外研究

Pre-incubation with A-804598 (0.1-10 μM; 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity.

Cell Cytotoxicity Assay

Cell Line:	microglial cell
Concentration:	0.1, 0.3, 1, 3, 10 μM
Incubation Time:	1 hour
Result:	Protected against BzATP-induced cytotoxicity in both inactivated and activated microglia.

体内研究

A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease.

Animal Model:	Adult B6.Cg-Tg (SOD1-G93A) 1Gur/J female mice
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; five times a week
Result:	Decreased SQSTM1/p62 expression.

安全信息

危险品标志	T
危险类别码	25
安全说明	45
危险品运输编号	UN 2811 6.1 / PGIII
WGK Germany	3
存储类别	6.1C - 可燃，急性毒性类别3 毒性化合物或者引起慢性影响的化合物
危险性类别	急性毒性类别3经口

MSDS信息

1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/06/05	HY-100483	A-804598	1125758-85-1	1 mg	300元
2026/06/05	HY-100483	1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE A-804598	1125758-85-1	5mg	550元

1-CYANO-2-[(1S)-1-PHENYLETHYL]-3-QUINOLIN-5-YLGUANIDINE