1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine CAS#: 1380088-03-8

1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine

生物活性靶点体外研究用途与合成方法 MSDS 1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine价格(试剂级) 上下游产品信息

中文名称	1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine
中文同义词	化合物 T11745;化合物 KB SRC 4;1-[3-[1-([1,1′-联苯]-3-基甲基)-1H-1,2,3-三唑-5-基]苯基]-3-(4-氯苯基)-1H-吡唑并[3,4-D]嘧啶-4-胺;1-[3-[1-([1,1'-BIPHENYL]-3-YLMETHYL)-1H-1,2,3-TRIAZOL-5-YL]PHENYL]-3-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
英文名称	1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine
英文同义词	1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine;KB SRC 4;KB SRC 4 (c-Src-IN-4);1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-[3-[1-([1,1'-biphenyl]-3-ylmethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-
CAS号	1380088-03-8
分子式	C32H23ClN8
分子量	555.03
EINECS号
相关类别	Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors
Mol文件	1380088-03-8.mol
结构式

1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine 性质

沸点	789.2±70.0 °C(Predicted)
密度	1.39±0.1 g/cm3(Predicted)
储存条件	Store at -20°C
溶解度	在 DMSO 中溶解度为 20 mM
形态	粉末
酸度系数(pKa)	3.46±0.30(Predicted)
颜色	浅棕色至棕色

1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine 用途与合成方法

生物活性

KB SRC 4 是一种有效的，高度选择性的 c-Src 抑制剂，Ki 和 Kd 值分别为 44 nM 和 86 nM，在浓度高达 125 μM 时，对 c-Abl 也无作用；KB SRC 4 具有抗肿瘤活性。

靶点

Ki: 44 nM (c-Src)
Kd: 86 nM (c-Src)

体外研究

KB SRC 4 (Compound 4) is a potent, highly selective c-Src inhibitor, with a K _i of 44 nM and a K _d of 86 nM, and shows no inhibition on c-Abl up to 125 μM. KB SRC 4 is selective between Src family members, with >2-fold selectivity over both Lck (K _d , 160 nM) and Fgr (K _d , 240 nM), 8-fold selectivity over c-Yes (K _d , 720 nM), and >40-fold selectivity over Lyn (K _d , 3200 nM), Hck (K _d , 4400 nM), and Fyn (K _d , >40000 nM). KB SRC 4 inhibits the growth of cancer cell lines, with GI ₅₀ s of 11 μM, 12 μM, 11 μM, 6.0 μM against HT-29, SK-BR-3, MCF7, MDA-MB-453, and NIH-3T3, respectively.

安全信息

MSDS信息

1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/09/15	HY-108488	KB SRC 4	1380088-03-8	5 mg	2200元
2026/09/15	HY-108488	KB SRC 4	1380088-03-8	10 mM * 1 mLin DMSO	2686元

1-[3-[1-([1,1'-Biphenyl]-3-ylMethyl)-1H-1,2,3-triazol-5-yl]phenyl]-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine